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Displaying record number 57432

HXB2 Location Gag(216-224) Gag Epitope Map
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Epitope

HPVHAGPVA

Epitope Alignment

Variants

HPVHAGPVp non-susceptible form; susceptible form

Epitope Name HA9

Species (MHC/HLA) human(B7 supertype)

Variant Details

Showing 1 of 8 variants.

Variant ID.	`2475`
Epitope Seq.	`HPVHAGPVA`
Variant Seq.	`HPVHAGPVp`
Mutations	A/P
Epitope Location	A9P
HXB2 Location	A224P
Mutation Type	NSF: non-susceptible form SF: susceptible form
Epitope Subtype	A1, C, D
Variant Subtype	C, D
Method	CD8 T-cell Elispot - IFNy
Note	Patients 2295 (Caucasian female, experienced some treatment, autologous virus Clade C) and 2840 (African female, treated, autologous virus Clade D) continued to elicit response to variant HPVHAGPVp, but cells encountering this variant were not susceptible in patient 2632 (African female, experienced some treatment, autologous virus Clade A1).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.