HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 57432

HXB2 Location  Gag(216-224)   Gag Epitope Map
View variants at this location
Epitope HPVHAGPVA   Epitope Alignment
HPVHAGPVp   non-susceptible form; susceptible form
Epitope Name HA9
Species (MHC/HLA human(B7 supertype)

Variant Details

Showing 1 of 8 variants.

Variant ID.  2475
Epitope Seq.  HPVHAGPVA
Variant Seq.  HPVHAGPVp
Mutations A/P
Epitope Location A9P
HXB2 Location A224P
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype A1, C, D
Variant Subtype C, D
Method CD8 T-cell Elispot - IFNy
Note Patients 2295 (Caucasian female, experienced some treatment, autologous virus Clade C) and 2840 (African female, treated, autologous virus Clade D) continued to elicit response to variant HPVHAGPVp, but cells encountering this variant were not susceptible in patient 2632 (African female, experienced some treatment, autologous virus Clade A1).


Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

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