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Found 1 matching record:

Displaying record number 57416

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
rAFSPEiIPMF   diminished HLA binding or increased off-rate; literature escape
Epitope Name KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing 1 of 2 variants.


Variant ID.  2364
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rAFSPEiIPMF
Mutations K/R V/I
Epitope Location K1R V7I
HXB2 Location K162R V168I
Mutation Type DHB: diminished HLA binding or increased off-rate
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This rare escape was seen in subject CH-13, a controller. CH-13 also displayed a rare substitution in epitope TW10 (TSTLQEQIGW), suggesting that the two rare mutational pathways may be inter-dependent. Avidity of this variant, rAFSPEiIPMF, was much lower than that of wild type KF11.

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


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