Found 1 matching record:
HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
Variants |
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Epitope Name | KF11 | |||||
Species (MHC/HLA) | human(B*57) |
Showing 1 of 2 variants.
Variant ID. | 2363 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KnFSPEVIPMF |
Mutations | A/N |
Epitope Location | A2N |
HXB2 Location | A163N |
Mutation Type | DHB: diminished HLA binding or increased off-rate LE: literature escape |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Controller subject CH-22 had the A163X escape that has a fitness cost. CH-22 lacked the partially compensating mutation S165X, however. Variant A163N was recognized with a lower avidity than wild type KF11. |
Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.
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