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Found 1 matching record:

Displaying record number 57381

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiAvL   literature escape
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 3 variants.


Variant ID.  2340
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note SL9 variant V82I/T84V, SLYNTiAvL, was recognized by different TCR mutants with differing functional avidities.

References

Bennett2010 Michael S. Bennett, Aviva Joseph, Hwee L. Ng, Harris Goldstein, and Otto O. Yang. Fine-Tuning of T-Cell Receptor Avidity to Increase HIV Epitope Variant Recognition by Cytotoxic T Lymphocytes. AIDS, 24(17):2619-2628, 13 Nov 2010. PubMed ID: 20881472. Show all entries for this paper.


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