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Displaying record number 53648

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
{p}lSPRTLNAW   inferred escape; processing
Epitope Name ISW9
Species (MHC/HLA human(B*58:01, B57)

Variant Details

Showing 1 of 2 variants.


Variant ID.  2324
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {p}lSPRTLNAW
Mutations A/P I/L
Epitope Location A-1P I1L
HXB2 Location A146P I147L
Mutation Type IE: inferred escape
P: processing
Method Sequence
Note ISPRTLNAW was recognized more often in children than in adults, and was the most frequently recognized B57 epitope in children. Longitudinal sequencing of 2 HLA B57 children born to HLA B57-negative mothers and HIV-negative fathers showed variants of this epitope: {p}lSPRTLNAW, and lSPRTLNAW. In both cases the mother carried {A}ISPRTLNAW, confirming that the mutations arose under selection pressure in the children following vertical transmission. Response to the variants was not studied, but a processing escape was assumed.

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


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