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Displaying record number 52827

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

KIRLRPGGK{*t} escape documented in this paper; processing

Epitope Name A3-KK9 Gag

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2281`
Epitope Seq.	`KIRLRPGGK{*R}`
Variant Seq.	`KIRLRPGGK{*t}`
Mutations	R/T
Epitope Location	R+2T
HXB2 Location	R28T
Mutation Type	E: escape documented in this paper P: processing
Method	CD8 T-cell Elispot - IFNy
Note	Response declined over time; authors suggested that the decline was due to a downstream Arg -> Thr substitution at C+2 that may impair processing.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.