HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 52827

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGK{*t}   escape documented in this paper; processing
Epitope Name A3-KK9 Gag
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2281
Epitope Seq.  KIRLRPGGK{*R}
Variant Seq.  KIRLRPGGK{*t}
Mutations R/T
Epitope Location R+2T
HXB2 Location R28T
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy
Note Response declined over time; authors suggested that the decline was due to a downstream Arg -> Thr substitution at C+2 that may impair processing.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health