HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 52827

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
KIRLRPGGK{*t}   escape documented in this paper; processing
Epitope Name A3-KK9 Gag
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.  2281
Epitope Seq.  KIRLRPGGK{*R}
Variant Seq.  KIRLRPGGK{*t}
Mutations R/T
Epitope Location R+2T
HXB2 Location R28T
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy
Note Response declined over time; authors suggested that the decline was due to a downstream Arg -> Thr substitution at C+2 that may impair processing.


Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.

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