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Displaying record number 54495

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYNaVATL escape documented in this paper; TCR related mutation

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 22 variants.

Variant ID.	`2250`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNaVATL`
Mutations	T/A
Epitope Location	T5A
HXB2 Location	T81A
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

References

Martinez-Hackert2006 Erik Martinez-Hackert, Nadia Anikeeva, Spyros A. Kalams, Bruce D. Walker, Wayne A. Hendrickson, and Yuri Sykulev. Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes. J. Biol. Chem., 281(29):20205-20212, 21 Jul 2006. PubMed ID: 16702212. Show all entries for this paper.