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Found 1 matching record:

Displaying record number 54495

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNlVAvL   escape documented in this paper; TCR related mutation
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 22 variants.


Variant ID.  2248
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNlVAvL
Mutations T/L T/V
Epitope Location T5L T8V
HXB2 Location T81L T84V
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method Chromium-release assay, Sequence
Note This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

References

Martinez-Hackert2006 Erik Martinez-Hackert, Nadia Anikeeva, Spyros A. Kalams, Bruce D. Walker, Wayne A. Hendrickson, and Yuri Sykulev. Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes. J. Biol. Chem., 281(29):20205-20212, 21 Jul 2006. PubMed ID: 16702212. Show all entries for this paper.


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