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Found 1 matching record:

Displaying record number 1713

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope DTINEEAAEW   Epitope Alignment
Variants
eTINEEAAEW   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2210
Epitope Seq.  DTINEEAAEW
Variant Seq.  eTINEEAAEW
Mutations D/E
Epitope Location D1E
HXB2 Location D203E
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype B, C, D
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note DTINEEAAEW was not subtype A-specific and there was cross-recognition, although diminished, of the subtype B, C, and D variant, ETINEEAAEW.

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


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