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Found 1 matching record:

Displaying record number 55939

HXB2 Location  Gag(78-86)   Gag Epitope Map
View variants at this location
Epitope LFNTVATLY   Epitope Alignment
Variants
LyNTVATLY   observed variant
Epitope Name LY9(p17)
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1906
Epitope Seq.  LFNTVATLY
Variant Seq.  LyNTVATLY
Mutations F/Y
Epitope Location F2Y
HXB2 Location F79Y
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-A29 restricted and possibly HLA-B44 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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