HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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| Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | KF11 | |||||
| Species (MHC/HLA) | human(B*57:01, B*57:03) | |||||
Showing 1 of 16 variants.
| Variant ID. | 1890 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KgFkPEVIPMF |
| Mutations | A/G S/K |
| Epitope Location | A2G S4K |
| HXB2 Location | A163G S165K |
| Mutation Type | DHB: diminished HLA binding or increased off-rate SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form |
| Epitope Subtype | B, C |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding |
| Note | This variant is seen only in Clade C and binds HLA-B*5703. S164K variant is seen most frequently and is preferentially selected in context of HLA-B*5703. This A2G-S4K variant was recognized by HLA-B*5701- but not by -B*5703-expressing subjects, though avidity of recognition was reduced. |
Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.