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Found 1 matching record:

Displaying record number 55092

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFnPEVIPMF   diminished HLA binding or increased off-rate; subtype-specific non-susceptible form; subtype-specific susceptible form
Epitope Name KF11
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing 1 of 16 variants.


Variant ID.  1889
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type DHB: diminished HLA binding or increased off-rate
SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen only in Clade C and binds HLA-B*5703. S164N variant is seen most frequently and is preferentially selected in context of HLA-B*5703. This A2G-S4N variant was recognized by HLA-B*5701- but not by -B*5703-expressing subjects, though avidity of recognition was reduced.

References

Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.


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