HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(162-172)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human(B*57:01, B*57:03)|
Showing 1 of 16 variants.
|Mutation Type||SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
|Epitope Subtype||B, C|
|Variant Subtype||B, C|
|Method||CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding|
|Note||This variant is seen in both Clades B and C and binds HLA-B*5703 and -B*5701. A162N variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B*5703. This A2N variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.|
Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.