HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(28-36)|| Gag Epitope Map
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Showing 1 of 3 variants.
|Epitope Location||K3R I7L|
|HXB2 Location||K30R I34L|
|Mutation Type||E: escape documented in this paper
SF: susceptible form
|Note||This 3R variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed. Only 1/8 screened A24-positive individuals had CTL activity against this mutant.|
Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.