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Found 1 matching record:

Displaying record number 53158

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYKLKHIVW   Epitope Alignment
Variants
KYrLKHlVW   escape documented in this paper; processing; susceptible form
Species (MHC/HLA human(A24)

Variant Details

Showing 1 of 3 variants.


Variant ID.  1877
Epitope Seq.  KYKLKHIVW
Variant Seq.  KYrLKHlVW
Mutations K/R I/L
Epitope Location K3R I7L
HXB2 Location K30R I34L
Mutation Type E: escape documented in this paper
P: processing
SF: susceptible form
Method Chromium-release assay
Note This 3R variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed. Only 1/8 screened A24-positive individuals had CTL activity against this mutant.

References

Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.


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