HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(77-85)|| Gag Epitope Map
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Showing 1 of 6 variants.
|Epitope Location||Y3F V6I|
|HXB2 Location||Y79F V82I|
|Mutation Type||E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
TCR: TCR related mutation
|Method||Chromium-release assay, Relative replication capacity assay, Sequence|
|Note||CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.|
Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.