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Found 1 matching record:

Displaying record number 55700

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLhNTVATL   escape documented in this paper; TCR related mutation
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing 1 of 6 variants.


Variant ID.  1834
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNTVATL
Mutations Y/H
Epitope Location Y3H
HXB2 Location Y79H
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method Sequence, Surface Plasmon Resonance, TCR binding
Note This unusual SL9 escape variant was recognized poorly by patient 868 CTL, suggesting that viruses with this mutation would escape wild type TCR recognition. High affinity a11b6 TCR, however, did bind this variant well enough by surface plasmon resonance to predict recognition.

References

Varela-Rohena2008 Angel Varela-Rohena, Peter E. Molloy, Steven M. Dunn, Yi Li, Megan M. Suhoski, Richard G. Carroll, Anita Milicic, Tara Mahon, Deborah H. Sutton, Bruno Laugel, Ruth Moysey, Brian J. Cameron, Annelise Vuidepot, Marco A. Purbhoo, David K. Cole, Rodney E. Phillips, Carl H. June, Bent K. Jakobsen, Andrew K. Sewell, and James L. Riley. Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-Cell Receptor. Nat. Med., 14(12):1390-1385, Dec 2008. PubMed ID: 18997777. Show all entries for this paper.


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