HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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| Epitope |
SLYNTVATL
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | SL9 | |||||
| Species (MHC/HLA) | human(A*02) | |||||
Showing 1 of 6 variants.
| Variant ID. | 1832 |
|---|---|
| Epitope Seq. | SLYNTVATL |
| Variant Seq. | SLfNTVAvL |
| Mutations | Y/F T/V |
| Epitope Location | Y3F T8V |
| HXB2 Location | Y79F T84V |
| Mutation Type | SF: susceptible form |
| Method | Intracellular cytokine staining, Sequence, TCR binding |
| Note | This naturally occurring variant was recognized by a CTL line from patient 868. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response, though this binding was the weakest of all variants tested. |
Varela-Rohena2008 Angel Varela-Rohena, Peter E. Molloy, Steven M. Dunn, Yi Li, Megan M. Suhoski, Richard G. Carroll, Anita Milicic, Tara Mahon, Deborah H. Sutton, Bruno Laugel, Ruth Moysey, Brian J. Cameron, Annelise Vuidepot, Marco A. Purbhoo, David K. Cole, Rodney E. Phillips, Carl H. June, Bent K. Jakobsen, Andrew K. Sewell, and James L. Riley. Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-Cell Receptor. Nat. Med., 14(12):1390-1385, Dec 2008. PubMed ID: 18997777. Show all entries for this paper.