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Displaying record number 55064

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYNTVAvL diminished response

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`183`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T84V
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note	Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. SLYNTVAvL variant arose in one twin and not the other. Response to the variant was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.