HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 52917

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
pSPRTLNAW   escape documented in this paper; processing
Epitope Name ISW9
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).

Variant ID.  181
Epitope Seq.  ISPRTLNAW
Variant Seq.  pSPRTLNAW
Mutations I/P
Epitope Location I1P
HXB2 Location I147P
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note The A146P mutation flanking the ISW9 epitope, {p}ISPRTLNAW, is positively selected in HLA-B57+ persons and it prevents trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I. The A146P processing escape mutation does not influence replicative capacity of the virus in vitro and is accumulated over time in the human population.


Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.

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