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Displaying record number 52187

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   escape documented in this paper; susceptible form
Epitope Name SL9
Species (MHC/HLA  

Variant Details

Showing 1 of 3 variants.


Variant ID.  179
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type E: escape documented in this paper
SF: susceptible form
Note SLYNTVATL was the only form of the epitope found initially, but three alternate forms eventually appeared: SLYNTVAVL, SLYNTIATL, and most commonly SLYNTIAVL. These distinct forms bind A2, but have distinct abilities to stimulate different T-cell clonotypes. In subject TX7, the observed mutations of SL9 failed to escape overall CTL recognition, presumably because the six T-cell clonotypes allowed a more flexible response. The BV17 T-cell clone recognized SL9 but not SLYNTIAVL, and BV17 became undetectable at week 20 when SLYNTIAVL predominated. Subsequently BV17 became the second most common clone.

References

Douek2002 Daniel C. Douek, Michael R. Betts, Jason M. Brenchley, Brenna J. Hill, David R. Ambrozak, Ka-Leung Ngai, Nitin J. Karandikar, Joseph P. Casazza, and Richard A. Koup. A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape. J. Immunol., 168(6):3099-3104, 15 Mar 2002. PubMed ID: 11884484. Show all entries for this paper.


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