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Found 1 matching record:

Displaying record number 1712

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNMML   Epitope Alignment
Variants
TPQDLNtML   subtype-specific non-susceptible form; TCR related mutation
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  176
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNtML
Mutations M/T
Epitope Location M7T
HXB2 Location M186T
Mutation Type SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype A
Variant Subtype B, C, D
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note TPQDLNMML was subtype A-specific with no cross-recognition of the subtype B, C, and D variant, TPQDLNTML, although the B/C/D variant bound more efficiently to B53 in vitro. Position 7 shows great positional variation in crystal structures of two HLA-B53 complexes, suggesting that variation here might significantly alter the position of the peptide in the binding groove and thus affect TCR interactions.

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


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