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Found 1 matching record:

Displaying record number 178

HXB2 Location  Gag(173-192)   Gag Epitope Map
View variants at this location
Epitope SALSEGATPQDLNMMLNIVG   Epitope Alignment
Variants
SALSEGATPQDLNtMLNtVG   observed variant
Species (MHC/HLA human(B*81:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  172
Epitope Seq.  SALSEGATPQDLNMMLNIVG
Variant Seq.  SALSEGATPQDLNtMLNtVG
Mutations M/T I/T
Epitope Location M14T I18T
HXB2 Location M186T I190T
Mutation Type OV: observed variant
Epitope Subtype A
Variant Subtype B, C, D
Note CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope is distinct in subtype A relative to subtypes B, C, and D which share the dominant sequence: SALSEGATPQDLNTMLNTVG.

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.


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