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Displaying record number 178

HXB2 Location Gag(173-192) Gag Epitope Map
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Epitope

SALSEGATPQDLNMMLNIVG

Epitope Alignment

Variants

SALSEGATPQDLNtMLNtVG observed variant

Species (MHC/HLA) human(B*81:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`172`
Epitope Seq.	`SALSEGATPQDLNMMLNIVG`
Variant Seq.	`SALSEGATPQDLNtMLNtVG`
Mutations	M/T I/T
Epitope Location	M14T I18T
HXB2 Location	M186T I190T
Mutation Type	OV: observed variant
Epitope Subtype	A
Variant Subtype	B, C, D
Note	CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope is distinct in subtype A relative to subtypes B, C, and D which share the dominant sequence: SALSEGATPQDLNTMLNTVG.

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.