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Displaying record number 36

HXB2 Location Gag(21-40) Gag Epitope Map
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Epitope

LRPGGKKKYRLKHLVWASRE

Epitope Alignment

Variants

LRPGGKKKYkLKHiVWASRE subtype-specific non-susceptible form

Species (MHC/HLA) human(Cw4)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`170`
Epitope Seq.	`LRPGGKKKYRLKHLVWASRE`
Variant Seq.	`LRPGGKKKYkLKHiVWASRE`
Mutations	R/K L/I
Epitope Location	R10K L14I
HXB2 Location	R30K L34I
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	A
Variant Subtype	B
Note	CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope was defined in an A subtype infection -- the B clade variant (LRPGGKKKYKLKHIVWASRE) has two mutations relative to the A subtype form, and the CTLs from this patient were not A-B cross-reactive.

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.