HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 55367

HXB2 Location  Gag(80-88)   Gag Epitope Map
View variants at this location
Epitope NTVATLYCV   Epitope Alignment
NTVAvLYCV   observed variant
Epitope Name Gag 80
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 4 variants.

Variant ID.  1665
Epitope Seq.  NTVATLYCV
Variant Seq.  NTVAvLYCV
Mutations T/V
Epitope Location T5V
HXB2 Location T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt21 and Pt43 carried this variant and were unable to recognize the challenge HXB2 form, NTVATLYCV.


Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

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