HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(80-88)|| Gag Epitope Map
View variants at this location
|Epitope Name||Gag 80|
Showing 1 of 4 variants.
|Mutations||T/A V/I T/V|
|Epitope Location||T2A V3I T5V|
|HXB2 Location||T81A V82I T84V|
|Mutation Type||OV: observed variant|
|Method||CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence|
|Note||Subjects Pt15, Pt16, Pt18, Pt30, Pt33 and Pt35 carried this HXB2 epitope. All of the above were unable to recognize it however, except for Pt15 who did recognize the HXB2 sequence. Only Pt17 carried the variant NaiAvLYCV and was unable to cross-recognize the challenge HXB2 sequence.|
Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.