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Displaying record number 55367

HXB2 Location Gag(80-88) Gag Epitope Map
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Epitope

NTVATLYCV

Epitope Alignment

Variants

NaiAvLYCV observed variant

Epitope Name Gag 80

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 4 variants.

Variant ID.	`1664`
Epitope Seq.	`NTVATLYCV`
Variant Seq.	`NaiAvLYCV`
Mutations	T/A V/I T/V
Epitope Location	T2A V3I T5V
HXB2 Location	T81A V82I T84V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15, Pt16, Pt18, Pt30, Pt33 and Pt35 carried this HXB2 epitope. All of the above were unable to recognize it however, except for Pt15 who did recognize the HXB2 sequence. Only Pt17 carried the variant NaiAvLYCV and was unable to cross-recognize the challenge HXB2 sequence.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.