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Found 1 matching record:

Displaying record number 55395

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLnNaiAvL   observed variant
Epitope Name Gag 77
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 6 variants.


Variant ID.  1663
Epitope Seq.  SLYNTVATL
Variant Seq.  SLnNaiAvL
Mutations Y/N T/A V/I T/V
Epitope Location Y3N T5A V6I T8V
HXB2 Location Y79N T81A V82I T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope, and did not recognize the challenge HXB2 sequence SLYNTVATL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


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