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Displaying record number 55395

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLfNTVATL observed variant

Epitope Name Gag 77

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 6 variants.

Variant ID.	`1658`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15, Pt18 carried this variant epitope, but cross-recognized the challenge HXB2 sequence SLYNTVATL. Subject Pt30 who carried the challenge epitope too did not recognize that HXB2 sequence.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.