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Displaying record number 53841

HXB2 Location Gag(28-36) Gag Epitope Map
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Epitope

KYKLKHIVW

Epitope Alignment

Variants

qYKLKHIVW escape documented in this paper; literature escape

Epitope Name QW9

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1574`
Epitope Seq.	`KYKLKHIVW`
Variant Seq.	`qYKLKHIVW`
Mutations	K/Q
Epitope Location	K1Q
HXB2 Location	K28Q
Mutation Type	E: escape documented in this paper LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her HLA-A24-carrying infant, P-1189. Decreased recognition of the variant was seen relative to wild type index epitope. This variant was still detected at 12 months of age in infant P-1189. While the mother could recognize index epitope QW9, but not this variant, infant P-1189 could not recognize either index or variant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.