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Found 1 matching record:

Displaying record number 53839

HXB2 Location  Gag(20-29)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGKKrY   diminished response
Epitope Name RY10
Species (MHC/HLA human(A*30)

Variant Details

Showing 1 of 2 variants.


Variant ID.  1572
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKrY
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1002, as well as her HLA-A30-carrying infant, P-1031. Decreased recognition of the variant was seen relative to index epitope in the mother. The variant was detected at decreasing frequencies by 11 months of age in infant P-1031, but recognition was equivalent to index epitope recognition in the infant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


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