HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(20-29) | Gag Epitope Map
View variants at this location |
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| Epitope |
RLRPGGKKKY
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | RY10 | |||||
| Species (MHC/HLA) | human(A*30) | |||||
Showing 1 of 2 variants.
| Variant ID. | 1572 |
|---|---|
| Epitope Seq. | RLRPGGKKKY |
| Variant Seq. | RLRPGGKKrY |
| Mutations | K/R |
| Epitope Location | K9R |
| HXB2 Location | K28R |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1002, as well as her HLA-A30-carrying infant, P-1031. Decreased recognition of the variant was seen relative to index epitope in the mother. The variant was detected at decreasing frequencies by 11 months of age in infant P-1031, but recognition was equivalent to index epitope recognition in the infant. |
Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.