Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 40

HXB2 Location Gag(24-31) Gag Epitope Map
View variants at this location

Epitope

GGKKKYKL

Epitope Alignment

Variants

GGKKqYKL escape documented in this paper

Species (MHC/HLA) human(B8)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`1440`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGKKqYKL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K28Q
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	Chromium-release assay, HLA binding
Note	This variant from the index was seen from the earliest recorded time point. It is either an escape that became fixed or infection occurred with the virus bearing variant Q5. Diminished recognition by index epitope-specific CTL was measured.

References

Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.