HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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| Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | KF11 | |||||
| Species (MHC/HLA) | human(B*57:03) | |||||
Showing 1 of 3 variants.
| Variant ID. | 139 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KnFSPEVIPMF |
| Mutations | A/N |
| Epitope Location | A2N |
| HXB2 Location | A163N |
| Mutation Type | NSF: non-susceptible form SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy |
| Note | 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, and KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form. Responses against KnFSPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF and there was little or no response in subjects carrying KgFnPEVIPMF. |
Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.