HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 53635

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
KnFSPEVIPMF   non-susceptible form; susceptible form
Epitope Name KF11
Species (MHC/HLA human(B*57:03)

Variant Details

Showing 1 of 3 variants.

Variant ID.  139
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, and KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form. Responses against KnFSPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF and there was little or no response in subjects carrying KgFnPEVIPMF.


Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.

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