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Displaying record number 53414

HXB2 Location Gag(213-232) Gag Epitope Map
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Epitope

DRLHPVHAGPAAPGQMREPR

Epitope Alignment

Variants

DRLHPVHAGPiAPGQMREPR diminished response

Epitope Name DRL

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1353`
Epitope Seq.	`DRLHPVHAGPAAPGQMREPR`
Variant Seq.	`DRLHPVHAGPiAPGQMREPR`
Mutations	A/I
Epitope Location	A11I
HXB2 Location	A223I
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Diminished response at higher peptide concentration, similar response at lower peptide concentration.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.