HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(77-85)|| Gag Epitope Map
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Showing 1 of 2 variants.
|Epitope Location||F3Y T5A|
|HXB2 Location||F79Y T81A|
|Mutation Type||E: escape documented in this paper|
|Method||CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding|
|Note||Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.|
Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.