HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 53411

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLyNaVATL   escape documented in this paper
Epitope Name SLF
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 2 variants.


Variant ID.  1350
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNaVATL
Mutations F/Y T/A
Epitope Location F3Y T5A
HXB2 Location F79Y T81A
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health