HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 53411

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
SLyNTVATL   escape documented in this paper
Epitope Name SLF
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 2 variants.

Variant ID.  1349
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.

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