HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 46

HXB2 Location  Gag(24-32)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKLK   Epitope Alignment
GGrKKYKLK   escape documented in this paper; susceptible form
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.  1344
Epitope Seq.  GGKKKYKLK
Variant Seq.  GGrKKYKLK
Mutations K/R
Epitope Location K3R
HXB2 Location K26R
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note Both K and R variants bind HLA-B8. The predominant variant shifts from K to R, back to K. R variant is never recognized; but the K variant is initially recognized, loses recognition and begins to gain recognition by CTL again.


Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.

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