HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(24-32) | Gag Epitope Map
View variants at this location |
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| Epitope |
GGKKKYKLK
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(B8) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1344 |
|---|---|
| Epitope Seq. | GGKKKYKLK |
| Variant Seq. | GGrKKYKLK |
| Mutations | K/R |
| Epitope Location | K3R |
| HXB2 Location | K26R |
| Mutation Type | E: escape documented in this paper SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study |
| Note | Both K and R variants bind HLA-B8. The predominant variant shifts from K to R, back to K. R variant is never recognized; but the K variant is initially recognized, loses recognition and begins to gain recognition by CTL again. |
Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.