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Search the Epitope Variant and Escape Mutation Database


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Displaying record number 53822

HXB2 Location  Gag(93-101)   Gag Epitope Map
View variants at this location
Epitope EVKDTKEAL   Epitope Alignment
dVKDTKEAL   escape documented in this paper; susceptible form
Species (MHC/HLA human(B*08:01)

Variant Details

Showing 1 of 2 variants.

Variant ID.  1309
Epitope Seq.  EVKDTKEAL
Variant Seq.  dVKDTKEAL
Mutations E/D
Epitope Location E1D
HXB2 Location E93D
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant was found in Donor2 and Recipient2 both of whom were restricting HLA-B*0801 carriers. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time.


Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.

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