Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 53822

HXB2 Location Gag(93-101) Gag Epitope Map
View variants at this location

Epitope

EVKDTKEAL

Epitope Alignment

Variants

dVKgTKEAL escape documented in this paper

Species (MHC/HLA) human(B*08:01)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`1308`
Epitope Seq.	`EVKDTKEAL`
Variant Seq.	`dVKgTKEAL`
Mutations	E/D D/G
Epitope Location	E1D D4G
HXB2 Location	E93D D96G
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant was found in Donor2 but not transmitted to Recipient2. The variant was not recognized by CTL. Both donor and recipient carried the restricting HLA-B*0801 allele

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.