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Found 1 matching record:

Displaying record number 53821

HXB2 Location  Gag(71-79)   Gag Epitope Map
View variants at this location
Epitope GSEELRSLY   Epitope Alignment
Variants
GSEEikSLY   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1306
Epitope Seq.  GSEELRSLY
Variant Seq.  GSEEikSLY
Mutations L/I R/K
Epitope Location L5I R6K
HXB2 Location L75I R76K
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-A*0101 allele. It was not recognized and binding to HLA was reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


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