HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(197-205) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
ANQMLKDTI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | mouse(H-2d) | |||||
Showing all: 1 variant(s).
| Variant ID. | 121 |
|---|---|
| Epitope Seq. | ANQMLKDTI |
| Variant Seq. | ANQMLKeTI |
| Mutations | D/E |
| Epitope Location | D7E |
| HXB2 Location | D203E |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | C |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, CD8 T-cell Elispot - IFNy, Cytokine production, Cytolytic LDH release assay |
| Note | A cross-clade response to the C clade epitope ANQMLKDTI was observed to the B clade version of this epitope, aNqmlkEti. 66% lysis was observed to the peptide carrying the C clade epitope, only 33% to the B clade variant. |
Chugh2004 Priti Chugh and Pradeep Seth. Induction of Broad-Based Immune Response against HIV-1 Subtype C gag DNA Vaccine in Mice. Viral Immunol., 17(3):423-435, 2004. Erratum in Viral Immunol. 2004;17(4):620. PubMed ID: 15357908. Show all entries for this paper.