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Found 1 matching record:

Displaying record number 53633

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKr   susceptible form
Species (MHC/HLA human(A3, A30, B42, B62)

Variant Details

Showing 1 of 2 variants.


Variant ID.  115
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKr
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note The majority of viral sequences prior to therapy were rlrpggkkQ. At week 14 of therapy a major change in the viral quasispecies occurred: the variants present were found to be rlrpggkkK (14/16 clones) and rlrpggkkR (2/16 clones), both well recognized by HIV-specific CD8 T cells. At week 19, the quasispecies reverted back to the less well-recognized rlrpggkkQ variant.

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


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