HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(20-28)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human(A3, A30, B42, B62)|
Showing 1 of 2 variants.
|Mutation Type||SF: susceptible form|
|Method||Flow cytometric T-cell cytokine assay, Intracellular cytokine staining|
|Note||The majority of viral sequences prior to therapy were rlrpggkkQ. At week 14 of therapy a major change in the viral quasispecies occurred: the variants present were found to be rlrpggkkK (14/16 clones) and rlrpggkkR (2/16 clones), both well recognized by HIV-specific CD8 T cells. At week 19, the quasispecies reverted back to the less well-recognized rlrpggkkQ variant.|
Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.