Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
||||
---|---|---|---|---|---|---|
Epitope |
TSTLQEQIGW
|
Epitope Alignment | ||||
Variants |
|
|||||
Epitope Name | TW10 | |||||
Species (MHC/HLA) | human(B*57, B*58:01) |
Showing 1 of 12 variants.
Variant ID. | 1078 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIaW |
Mutations | G/A |
Epitope Location | G9A |
HXB2 Location | G248A |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence |
Note | This variant was found in 6/80 HLA-B*57/58 subjects, but only in 17/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. It arises commonly and at no cost to the virus and is readily transmitted to persistence in restricting HLA negative subjects, is not correlated with compensations and increases viral infectivity. It is however, relatively ineffective as an escape with only partial loss of recognition. |
Martinez-Picado2006 Javier Martinez-Picado, Julia G. Prado, Elizabeth E. Fry, Katja Pfafferott, Alasdair Leslie, Senica Chetty, Christina Thobakgale, Isobel Honeyborne, Hayley Crawford, Philippa Matthews, Tilly Pillay, Christine Rousseau, James I. Mullins, Christian Brander, Bruce D. Walker, David I. Stuart, Photini Kiepiela, and Philip Goulder. Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1. J. Virol., 80(7):3617-3623, Apr 2006. PubMed ID: 16537629. Show all entries for this paper.
This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.