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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 54216

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLQEQIaW   diminished response
Epitope Name TW10
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing 1 of 12 variants.


Variant ID.  1078
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence
Note This variant was found in 6/80 HLA-B*57/58 subjects, but only in 17/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. It arises commonly and at no cost to the virus and is readily transmitted to persistence in restricting HLA negative subjects, is not correlated with compensations and increases viral infectivity. It is however, relatively ineffective as an escape with only partial loss of recognition.

References

Martinez-Picado2006 Javier Martinez-Picado, Julia G. Prado, Elizabeth E. Fry, Katja Pfafferott, Alasdair Leslie, Senica Chetty, Christina Thobakgale, Isobel Honeyborne, Hayley Crawford, Philippa Matthews, Tilly Pillay, Christine Rousseau, James I. Mullins, Christian Brander, Bruce D. Walker, David I. Stuart, Photini Kiepiela, and Philip Goulder. Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1. J. Virol., 80(7):3617-3623, Apr 2006. PubMed ID: 16537629. Show all entries for this paper.


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