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Found 1 matching record:

Displaying record number 54533

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKh   diminished response
Epitope Name RK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1020
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKh
Mutations K/H
Epitope Location K9H
HXB2 Location K28H
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition of the variant is seen with both C- and A-clades. The C-clade variant contains a change at position 9 to RLRPGGKKh. Typically, magnitude and avidity of binding for T-cell responses were much lower to the C-clade variant.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


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