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Displaying record number 54533

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

RLRPGGKKh diminished response

Epitope Name RK9

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1020`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKh`
Mutations	K/H
Epitope Location	K9H
HXB2 Location	K28H
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy
Note	Cross-recognition of the variant is seen with both C- and A-clades. The C-clade variant contains a change at position 9 to RLRPGGKKh. Typically, magnitude and avidity of binding for T-cell responses were much lower to the C-clade variant.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.