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Displaying record number 53386

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYaTVATL diminished response; escape documented in this paper; TCR related mutation

Epitope Name gag 77-85

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 8 variants.

Variant ID.	`1008`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYaTVATL`
Mutations	N/A
Epitope Location	N4A
HXB2 Location	N80A
Mutation Type	DR: diminished response E: escape documented in this paper TCR: TCR related mutation
Method	CD8 T-cell Elispot - IFNy
Note	Artificially synthesized variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.