HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(77-85)|| Gag Epitope Map
View variants at this location
|Epitope Name||gag 77-85|
Showing 1 of 8 variants.
|Epitope Location||Y3F T5A|
|HXB2 Location||Y79F T81A|
|Mutation Type||DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
|Method||CD8 T-cell Elispot - IFNy|
|Note||Naturally-occurring clade G variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.|
Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.