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Found 1 matching record:

Displaying record number 53386

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNaVATL   diminished response; escape documented in this paper; subtype-specific non-susceptible form; TCR related mutation
Epitope Name gag 77-85
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 8 variants.


Variant ID.  1006
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaVATL
Mutations Y/F T/A
Epitope Location Y3F T5A
HXB2 Location Y79F T81A
Mutation Type DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype G
Method CD8 T-cell Elispot - IFNy
Note Naturally-occurring clade G variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.


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