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Displaying record number 55092

HXB2 Location Gag(162-172) Gag Epitope Map
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KAFSPEVIPMF

`KgFSPEVIPMF`		subtype-specific non-susceptible form; subtype-specific susceptible form
`KnFSPEVIPMF`		subtype-specific non-susceptible form; subtype-specific susceptible form
`KsFSPEVIPMF`		observed variant
`KgFnPEVIPMF`		diminished HLA binding or increased off-rate; subtype-specific non-susceptible form; subtype-specific susceptible form
`KgFkPEVIPMF`		diminished HLA binding or increased off-rate; subtype-specific non-susceptible form; subtype-specific susceptible form
`KsFSPEtIPMF`		observed variant
`KAFSPEiIPMF`		subtype-specific susceptible form
`KsFSPEiIPMF`		observed variant
`KAFnPEVIPMF`		observed variant
`KAFnPEiIPMF`		observed variant
`rAFSPEVIPMF`		observed variant
`KAFSPkVIPMF`		observed variant
`KAlSPEVIPMF`		susceptible form
`KAFSPEVIPvF`		susceptible form
`KAFSqEVIPMF`		non-susceptible form
`KAFSPEaIPMF`		observed variant

Epitope Name KF11

Species (MHC/HLA) human(B*57:01, B*57:03)

Variant Details

Showing all: 16 variant(s).

Variant ID.	`1885`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KgFSPEVIPMF`
Mutations	A/G
Epitope Location	A2G
HXB2 Location	A163G
Mutation Type	SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form
Epitope Subtype	B, C
Variant Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note	This variant is seen in both Clades B and C and binds HLA-B5703. A162G variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B5703. This A2G variant was recognized by HLA-B5701- and -B5703-expressing subjects.

Variant ID.	`1886`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KnFSPEVIPMF`
Mutations	A/N
Epitope Location	A2N
HXB2 Location	A163N
Mutation Type	SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form
Epitope Subtype	B, C
Variant Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note	This variant is seen in both Clades B and C and binds HLA-B5703 and -B5701. A162N variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B5703. This A2N variant was recognized by HLA-B5701- and -B*5703-expressing subjects.

Variant ID.	`1887`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KsFSPEVIPMF`
Mutations	A/S
Epitope Location	A2S
HXB2 Location	A163S
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	B, C
Method	Sequence
Note	This variant is seen in both Clades B and C and binds HLA-B5703. A162S variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B5703.

Variant ID.	`1889`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KgFnPEVIPMF`
Mutations	A/G S/N
Epitope Location	A2G S4N
HXB2 Location	A163G S165N
Mutation Type	DHB: diminished HLA binding or increased off-rate SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note	This variant is seen only in Clade C and binds HLA-B5703. S164N variant is seen most frequently and is preferentially selected in context of HLA-B5703. This A2G-S4N variant was recognized by HLA-B5701- but not by -B5703-expressing subjects, though avidity of recognition was reduced.

Variant ID.	`1890`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KgFkPEVIPMF`
Mutations	A/G S/K
Epitope Location	A2G S4K
HXB2 Location	A163G S165K
Mutation Type	DHB: diminished HLA binding or increased off-rate SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note	This variant is seen only in Clade C and binds HLA-B5703. S164K variant is seen most frequently and is preferentially selected in context of HLA-B5703. This A2G-S4K variant was recognized by HLA-B5701- but not by -B5703-expressing subjects, though avidity of recognition was reduced.

Variant ID.	`1892`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KsFSPEtIPMF`
Mutations	A/S V/T
Epitope Location	A2S V7T
HXB2 Location	A163S V168T
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	C
Method	Sequence
Note	This variant is seen only in Clade C and binds HLA-B*5703.

Variant ID.	`1893`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEiIPMF`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V168I
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note	This variant is seen only in Clade C and binds HLA-B5701. The V7I variant was recognized by HLA-B5701- and -B*5703-expressing subjects.

Variant ID.	`1894`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KsFSPEiIPMF`
Mutations	A/S V/I
Epitope Location	A2S V7I
HXB2 Location	A163S V168I
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	B
Method	Sequence
Note	This variant is seen only in Clade B and binds HLA-B*5703.

Variant ID.	`1895`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFnPEVIPMF`
Mutations	S/N
Epitope Location	S4N
HXB2 Location	S165N
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	B, C
Method	Sequence
Note	This variant was seen only in non-HLA-B57 carriers, in both Clades B and C sequences.

Variant ID.	`1896`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFnPEiIPMF`
Mutations	S/N V/I
Epitope Location	S4N V7I
HXB2 Location	S165N V168I
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	C
Method	Sequence
Note	This variant was seen only in non-HLA-B57 carriers, and only in their Clade C sequences.

Variant ID.	`1897`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`rAFSPEVIPMF`
Mutations	K/R
Epitope Location	K1R
HXB2 Location	K162R
Mutation Type	OV: observed variant
Epitope Subtype	B, C
Variant Subtype	B, C
Method	Sequence
Note	This variant was seen only in non-HLA-B57 carriers, in both Clades B and C sequences.

Variant ID.	`1898`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPkVIPMF`
Mutations	E/K
Epitope Location	E6K
HXB2 Location	E167K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	C
Method	Sequence
Note	This variant was seen only in non-HLA-B57 carriers, and only in Clade C sequences.

Variant ID.	`1900`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAlSPEVIPMF`
Mutations	F/L
Epitope Location	F3L
HXB2 Location	F164L
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	The F3L variant was recognized by HLA-B5701- and -B5703-expressing subjects.

Variant ID.	`1901`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEVIPvF`
Mutations	M/V
Epitope Location	M10V
HXB2 Location	M171V
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	The M10V variant was recognized by HLA-B5701- and -B5703-expressing subjects.

Variant ID.	`1902`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSqEVIPMF`
Mutations	P/Q
Epitope Location	P5Q
HXB2 Location	P166Q
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	The P5Q variant was not recognized by HLA-B5701- and -B5703-expressing subjects.

Variant ID.	`2268`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEaIPMF`
Mutations	V/A
Epitope Location	V7A
HXB2 Location	V168A
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	B
Method	Sequence
Note	This variant was seen only in non-HLA-B57 carriers, and only in Clade B sequences.

References

Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.