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Found 45 matching records:

Displaying record number 63007

HXB2 Location Gag(113-130) Gag Epitope Map
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Epitope

KKAQQAAADTGNSSQVSQ

Epitope Alignment

Variants

KKAQQAAADTGNSrQVSQ observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5124`
Epitope Seq.	`KKAQQAAADTGNSSQVSQ`
Variant Seq.	`KKAQQAAADTGNSrQVSQ`
Mutations	S/R
Epitope Location	S14R
HXB2 Location	S126R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant KKAQQAAADTGNSrQVSQ was observed, along with index peptide, at 6 mo following onset of symptoms, although response was no longer detected by 2 mo FOSx.

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.

Displaying record number 53223

HXB2 Location Gag(119-127) Gag Epitope Map
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Epitope

AADTGNSSQ

Epitope Alignment

Variants

`AADTGNgSQ`		escape documented in this paper
`eADTGNSSQ`		escape documented in this paper
`AADTkNSSQ`		escape documented in this paper
`AADTrNSSQ`		escape documented in this paper
`eADTGkSSQ`		escape documented in this paper
`AADTGNSSk`		escape documented in this paper
`AADTGsSSQ`		escape documented in this paper
`tADTGNSns`		escape documented in this paper
`AADTGNnnQ`		escape documented in this paper
`A-DTGNSSQ`		observed variant
`AAgTGNSSQ`		observed variant
`AADTeNSSQ`		observed variant
`AADTGN-S-(ss)`		escape documented in this paper
`tADTGN-Sn(s)`		escape documented in this paper
`AADTGNnS(ns)Q`		observed variant
`AADTGN-S(ss)Q`		escape documented in this paper

Epitope Name Gag AQ9

Species (MHC/HLA) human

Variant Details

Showing all: 16 variant(s).

Variant ID.	`507`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNgSQ`
Mutations	S/G
Epitope Location	S7G
HXB2 Location	S125G
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`508`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`eADTGNSSQ`
Mutations	A/E
Epitope Location	A1E
HXB2 Location	A119E
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`509`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTkNSSQ`
Mutations	G/K
Epitope Location	G5K
HXB2 Location	G123K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`510`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTrNSSQ`
Mutations	G/R
Epitope Location	G5R
HXB2 Location	G123R
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`511`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`eADTGkSSQ`
Mutations	A/E N/K
Epitope Location	A1E N6K
HXB2 Location	A119E N124K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`512`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNSSk`
Mutations	Q/K
Epitope Location	Q9K
HXB2 Location	Q127K
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`513`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGsSSQ`
Mutations	N/S
Epitope Location	N6S
HXB2 Location	N124S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`514`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`tADTGNSns`
Mutations	A/T S/N Q/S
Epitope Location	A1T S8N Q9S
HXB2 Location	A119T S126N Q127S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`515`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNnnQ`
Mutations	S/N S/N
Epitope Location	S7N S8N
HXB2 Location	S125N S126N
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`516`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`A-DTGNSSQ`
Mutations	A/-
Epitope Location	A2-
HXB2 Location	A120-
Mutation Type	OV: observed variant
Note	1/15 clones at time point 35.

Variant ID.	`517`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AAgTGNSSQ`
Mutations	D/G
Epitope Location	D3G
HXB2 Location	D121G
Mutation Type	OV: observed variant
Note	1/15 clones at time point 55.

Variant ID.	`518`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTeNSSQ`
Mutations	G/E
Epitope Location	G5E
HXB2 Location	G123E
Mutation Type	OV: observed variant
Note	2/15 clones at time point 55 and 1/15 clones at time point 65.

Variant ID.	`2285`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGN-S-(ss)`
Mutations	S/- Q/- -/S -/S
Epitope Location	S7- Q9- -(9.1)S -(9.2)S
HXB2 Location	S125- Q127- -(127.1)S -(127.2)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`2287`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`tADTGN-Sn(s)`
Mutations	A/T S/- Q/N -/S
Epitope Location	A1T S7- Q9N -(9.1)S
HXB2 Location	A119T S125- Q127N -(127.1)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

Variant ID.	`2288`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGNnS(ns)Q`
Mutations	S/N -/N -/S
Epitope Location	S7N -(8.1)N -(8.2)S
HXB2 Location	S125N -(126.1)N -(126.2)S
Mutation Type	OV: observed variant
Note	1/15 clones at time point 556.

Variant ID.	`2299`
Epitope Seq.	`AADTGNSSQ`
Variant Seq.	`AADTGN-S(ss)Q`
Mutations	S/- -/S -/S
Epitope Location	S7- -(8.1)S -(8.2)S
HXB2 Location	S125- -(126.1)S -(126.2)S
Mutation Type	E: escape documented in this paper
Note	Variant dramatically reduced CTL recognition.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Displaying record number 53224

HXB2 Location Gag(124-133) Gag Epitope Map
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Epitope

NSSQVSQNYP

Epitope Alignment

Variants

`NgSQVSQNYP`		diminished response
`NSSQaSQNYP`		diminished response
`sSSQVSQNYP`		diminished response
`NSSQdSQNYP`		diminished response
`NSSQgSQNYP`		diminished response
`kSSQVSQNYP`		diminished response
`NSSkVSQNYP`		diminished response
`NmnQVSQNYP`		diminished response
`NSS(s)QVSQNYP`		diminished response
`NS(n)SQVSQNYP`		diminished response
`NnS(ns)QVSQNYP`		diminished response

Epitope Name Gag NP10

Species (MHC/HLA) human

Variant Details

Showing all: 11 variant(s).

Variant ID.	`519`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NgSQVSQNYP`
Mutations	S/G
Epitope Location	S2G
HXB2 Location	S125G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`520`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQaSQNYP`
Mutations	V/A
Epitope Location	V5A
HXB2 Location	V128A
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`521`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`sSSQVSQNYP`
Mutations	N/S
Epitope Location	N1S
HXB2 Location	N124S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`522`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQdSQNYP`
Mutations	V/D
Epitope Location	V5D
HXB2 Location	V128D
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`523`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSQgSQNYP`
Mutations	V/G
Epitope Location	V5G
HXB2 Location	V128G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`524`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`kSSQVSQNYP`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N124K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`525`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSSkVSQNYP`
Mutations	Q/K
Epitope Location	Q4K
HXB2 Location	Q127K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`526`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NmnQVSQNYP`
Mutations	S/M S/N
Epitope Location	S2M S3N
HXB2 Location	S125M S126N
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2289`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NSS(s)QVSQNYP`
Mutations	-/S
Epitope Location	-(3.1)S
HXB2 Location	-(126.1)S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2290`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NS(n)SQVSQNYP`
Mutations	-/N
Epitope Location	-(2.1)N
HXB2 Location	-(125.1)N
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

Variant ID.	`2291`
Epitope Seq.	`NSSQVSQNYP`
Variant Seq.	`NnS(ns)QVSQNYP`
Mutations	S/N -/N -/S
Epitope Location	S2N -(3.1)N -(3.2)S
HXB2 Location	S125N -(126.1)N -(126.2)S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by diminishing CTL response.

References

Displaying record number 62978

HXB2 Location Gag(138-156) Gag Epitope Map
View variants at this location

Epitope

LQGQMVHQALSPRTLNAWV

Epitope Alignment

Variants

`LQGQMVHQAiSPRTLNAWV`		susceptible form
`LQGQMVHQAipPRTLNAWV`		observed variant
`LQGQMVHrAiSPRTLNAWV`		observed variant
`LQGQMVHQAiSlRTLNAWV`		observed variant
`LQGQMiHQAiSPRTLNAWV`		observed variant

Epitope Name Gag 138-156

Species (MHC/HLA) human

Variant Details

Showing all: 5 variant(s).

Variant ID.	`5089`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAiSPRTLNAWV`
Mutations	L/I
Epitope Location	L10I
HXB2 Location	L147I
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Longitudinal study
Note	Autologous susceptible form LQGQMVHQAiSPRTLNAWV was first observed in 9/15 clones at 17 days from the onset of symptoms (DFOSx) and persisted at frequencies of 13-15 per 15 clones through 556 DFOSx.

Variant ID.	`5090`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAipPRTLNAWV`
Mutations	L/I S/P
Epitope Location	L10I S11P
HXB2 Location	L147I S148P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHQAipPRTLNAWV was observed in 1/15 clones on 17 & 556 days from the onset of symptoms but was not observed in 5 intervening timepoints.

Variant ID.	`5091`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHrAiSPRTLNAWV`
Mutations	L/I Q/R
Epitope Location	L10I Q8R
HXB2 Location	L147I Q145R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHrAiSPRTLNAWV was observed in 1/15 clones in 1/6 sampled timepoints (35 days from the onset of symptoms).

Variant ID.	`5092`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMVHQAiSlRTLNAWV`
Mutations	L/I P/L
Epitope Location	L10I P12L
HXB2 Location	L147I P149L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMVHQAiSlRTLNAWV was observed in 1/15 clones in 1/6 sampled timepoints (65 days from the onset of symptoms).

Variant ID.	`5093`
Epitope Seq.	`LQGQMVHQALSPRTLNAWV`
Variant Seq.	`LQGQMiHQAiSPRTLNAWV`
Mutations	L/I V/I
Epitope Location	L10I V6I
HXB2 Location	L147I V143I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant LQGQMiHQAiSPRTLNAWV was observed in 1/15 clones on the last of 6 sampled timepoints (556 days from the onset of symptoms).

References

Displaying record number 57555

HXB2 Location Gag(240-249) Gag Epitope Map
View variants at this location

Epitope

TSTLQEQIGW

Epitope Alignment

Variants

TSnLQEQIGW escape documented in this paper

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2527`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIGW`
Mutations	T/N
Epitope Location	T3N
HXB2 Location	T242N
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD4 T-cell Elispot - IFNy
Note	The variant TSnLQEQIGW evolved to dominate the quasispecies, and was not recognized compared to the index peptide TSTLQEQIGW by the PBMC from time points around the time of response decline, indicating escape.

References

Displaying record number 63010

HXB2 Location Gag(429-446) Gag Epitope Map
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Epitope

RQANFLGKIWPPHKGRPG

Epitope Alignment

Variants

RQANFLGKIWsPHKGRPG observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5139`
Epitope Seq.	`RQANFLGKIWPPHKGRPG`
Variant Seq.	`RQANFLGKIWsPHKGRPG`
Mutations	P/S
Epitope Location	P11S
HXB2 Location	P439S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Note	Autologous variant RQANFLGKIWsPHKGRPG was observed at 6 months following onset of symptoms in patient MM43.

References

Displaying record number 63040

HXB2 Location Pol(81-98) Pol Epitope Map
View variants at this location

Epitope

DTGADDTVLEEMNLPGRW

Epitope Alignment

Variants

DTGADDTVLEdMNLPGRW observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5123`
Epitope Seq.	`DTGADDTVLEEMNLPGRW`
Variant Seq.	`DTGADDTVLEdMNLPGRW`
Mutations	E/D
Epitope Location	E11D
HXB2 Location	E91D
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant DTGADDTVLEdMNLPGRW was observed at 6 months following symptom onset in patient MM33.

References

Displaying record number 63043

HXB2 Location Pol(417-434) Pol Epitope Map
View variants at this location

Epitope

GKLNWASQIYAGIKVKQL

Epitope Alignment

Variants

GKLNWASQIYAGIKVrQL observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5147`
Epitope Seq.	`GKLNWASQIYAGIKVKQL`
Variant Seq.	`GKLNWASQIYAGIKVrQL`
Mutations	K/R
Epitope Location	K16R
HXB2 Location	K432R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	In MM33, autologous variant GKLNWASQIYAGIKVrQL was observed at 6 mo following onset of symptoms.

References

Displaying record number 63026

HXB2 Location Pol(825-842) Pol Epitope Map
View variants at this location

Epitope

VKAIHTDNGSNFTSAAVK

Epitope Alignment

Variants

VKAIHTDNGSNFiSAAVK observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5122`
Epitope Seq.	`VKAIHTDNGSNFTSAAVK`
Variant Seq.	`VKAIHTDNGSNFiSAAVK`
Mutations	T/I
Epitope Location	T13I
HXB2 Location	T837I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant VKAIHTDNGSNFiSAAVK was observed at 6 months following onset of symptoms in patient MM33.

References

Displaying record number 63091

HXB2 Location Vif(111-130) Vif Epitope Map
View variants at this location

Epitope

YFDCFSESAIRNAILGHIVS

Epitope Alignment

Variants

DCFSESAIRgAILGHIVS observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5109`
Epitope Seq.	`YFDCFSESAIRNAILGHIVS`
Variant Seq.	`DCFSESAIRgAILGHIVS`
Mutations	N/G
Epitope Location	N10G
HXB2 Location	N120G
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant DCFSESAIRgAILGHIVS, with a 2 AA truncation on the N-terminus relative to B cons, elicited a response in B-subtype acutely-infected patient MM43.

References

Displaying record number 63081

HXB2 Location Vif(113-130) Vif Epitope Map
View variants at this location

Epitope

DCFSESAIRGAILGHIVS

Epitope Alignment

Variants

`YFDCFSESAIRnAILGHIVS`		observed variant
`DCFSdSAIRGAILGHIVS`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5110`
Epitope Seq.	`DCFSESAIRGAILGHIVS`
Variant Seq.	`YFDCFSESAIRnAILGHIVS`
Mutations	G/N
Epitope Location	G10N
HXB2 Location	G122N
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons variant (YF)DCFSESAIRnAILGHIVS, with a 2 AA N-terminus extension relative to B cons indicated by parentheses, elicited a response in B-subtype acutely infected patient MM50.

Variant ID.	`5137`
Epitope Seq.	`DCFSESAIRGAILGHIVS`
Variant Seq.	`DCFSdSAIRGAILGHIVS`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E117D
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	Autologous variant DCFSdSAIRGAILGHIVS was observed at 6 mo following onset of symptoms in patient MM43.

References

Displaying record number 63082

HXB2 Location Vpr(9-26) Vpr Epitope Map
View variants at this location

Epitope

GPQREPFNEWTLELLEEL

Epitope Alignment

Variants

GPQRgPFNEWTLELLEEL observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5133`
Epitope Seq.	`GPQREPFNEWTLELLEEL`
Variant Seq.	`GPQRgPFNEWTLELLEEL`
Mutations	E/G
Epitope Location	E5G
HXB2 Location	E13G
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant GPQRgPFNEWTLELLEEL was observed, along with the index sequence, at 6 months following onset of symptoms.

References

Displaying record number 63083

HXB2 Location Vpr(73-90) Vpr Epitope Map
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Epitope

RIGCQHSRIGIIQRRRAR

Epitope Alignment

Variants

RIGCQHSRIGvIQRRRAR observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5132`
Epitope Seq.	`RIGCQHSRIGIIQRRRAR`
Variant Seq.	`RIGCQHSRIGvIQRRRAR`
Mutations	I/V
Epitope Location	I11V
HXB2 Location	I83V
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant RIGCQHSRIGvIQRRRAR was observed at 6 months following onset of symptoms.

References

Displaying record number 53225

HXB2 Location Tat(24-32) Tat Epitope Map
View variants at this location

Epitope

NCYCKKCCY

Epitope Alignment

Variants

`kCYCKKCCY`		escape documented in this paper
`kCYCKrCCY`		escape documented in this paper
`kCYCKqCCY`		escape documented in this paper
`NCYCKKyCY`		observed variant
`NCYCKKCCc`		observed variant
`NCYCKrCCf`		susceptible form

Epitope Name Tat NY9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`527`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKKCCY`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N24K
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 31, dramatically reduced CTL recognition.

Variant ID.	`528`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKrCCY`
Mutations	N/K K/R
Epitope Location	N1K K6R
HXB2 Location	N24K K29R
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 218, dramatically reduced CTL recognition.

Variant ID.	`529`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`kCYCKqCCY`
Mutations	N/K K/Q
Epitope Location	N1K K6Q
HXB2 Location	N24K K29Q
Mutation Type	E: escape documented in this paper
Note	Variant appeared by day 556, dramatically reduced CTL recognition.

Variant ID.	`530`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKKyCY`
Mutations	C/Y
Epitope Location	C7Y
HXB2 Location	C30Y
Mutation Type	OV: observed variant
Note	1/23 clones, transiently present at day 55.

Variant ID.	`531`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKKCCc`
Mutations	Y/C
Epitope Location	Y9C
HXB2 Location	Y32C
Mutation Type	OV: observed variant
Note	2/23 clones, transiently present at day 55.

Variant ID.	`5094`
Epitope Seq.	`NCYCKKCCY`
Variant Seq.	`NCYCKrCCf`
Mutations	K/R Y/F
Epitope Location	K6R Y9F
HXB2 Location	K29R Y32F
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay
Note	Please see CTL record #53233 for mutations in corresponding autologous variant NCYCKrCCf observed in subtype B-infected patient WEAU.

References

Displaying record number 53233

HXB2 Location Tat(24-32) Tat Epitope Map
View variants at this location

Epitope

NCYCKRCCF

Epitope Alignment

Variants

`kCYCKRCCF`		escape documented in this paper
`NCYCKkCCF`		observed variant
`tCYCKRCCF`		observed variant
`kCYCKsCCF`		observed variant
`kCYCKkCCF`		observed variant
`NCYCKkCCy`		susceptible form

Epitope Name Tat NF9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`532`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKRCCF`
Mutations	N/K
Epitope Location	N1K
HXB2 Location	N24K
Mutation Type	E: escape documented in this paper
Note	The CTL response diminished in vivo as this variant appeared. The variant was evident by day 72.

Variant ID.	`533`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`NCYCKkCCF`
Mutations	R/K
Epitope Location	R6K
HXB2 Location	R29K
Mutation Type	OV: observed variant
Note	1/7 clones, variant evident in samples taken at day 391.

Variant ID.	`534`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`tCYCKRCCF`
Mutations	N/T
Epitope Location	N1T
HXB2 Location	N24T
Mutation Type	OV: observed variant
Note	5/7 clones, variant evident in samples taken at day 772.

Variant ID.	`535`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKsCCF`
Mutations	N/K R/S
Epitope Location	N1K R6S
HXB2 Location	N24K R29S
Mutation Type	OV: observed variant
Note	1/9 clones, variant evident in samples taken at day 772.

Variant ID.	`536`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`kCYCKkCCF`
Mutations	N/K R/K
Epitope Location	N1K R6K
HXB2 Location	N24K R29K
Mutation Type	OV: observed variant
Note	1/9 clones, variant evident in samples taken at day 772.

Variant ID.	`5095`
Epitope Seq.	`NCYCKRCCF`
Variant Seq.	`NCYCKkCCy`
Mutations	R/K F/Y
Epitope Location	R6K F9Y
HXB2 Location	R29K F32Y
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Please see CTL record #53225 for mutations in corresponding autologous variant NCYCKkCCy observed in subtype B-infected patient BORI.

References

Displaying record number 63078

HXB2 Location Tat(31-50) Tat Epitope Map
View variants at this location

Epitope

CFHCQVCFITKGLGISYGRK

Epitope Alignment

Variants

HCQVCFIsKGLGISYGRK observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5111`
Epitope Seq.	`CFHCQVCFITKGLGISYGRK`
Variant Seq.	`HCQVCFIsKGLGISYGRK`
Mutations	T/S
Epitope Location	T10S
HXB2 Location	T40S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant HCQVCFIsKGLGISYGRK, with a 2 AA N-terminus truncation, elicited a CTL response in subtype B acutely-infected patient MM39.

References

Displaying record number 53235

HXB2 Location Tat(32-41) Tat Epitope Map
View variants at this location

Epitope

FHCQVCFMTK

Epitope Alignment

Variants

`FHCQVCFtTK`		escape documented in this paper
`FHCQVCFtTe`		observed variant
`lHCQVCFMkK`		escape documented in this paper

Epitope Name Tat FK10

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`537`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`FHCQVCFtTK`
Mutations	M/T
Epitope Location	M8T
HXB2 Location	M39T
Mutation Type	E: escape documented in this paper
Note	The variant was evident during acute phase of infection. The substitution abrogated responses to the epitope.

Variant ID.	`538`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`FHCQVCFtTe`
Mutations	K/E M/T
Epitope Location	K10E M8T
HXB2 Location	K41E M39T
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`539`
Epitope Seq.	`FHCQVCFMTK`
Variant Seq.	`lHCQVCFMkK`
Mutations	F/L T/K
Epitope Location	F1L T9K
HXB2 Location	F32L T40K
Mutation Type	E: escape documented in this paper
Note	The double mutation was evident at day 69 and the variant was not recognized.

References

Displaying record number 63080

HXB2 Location Tat(33-50) Tat Epitope Map
View variants at this location

Epitope

HCQVCFISKGLGISYGRK

Epitope Alignment

Variants

`CFHCQVCFItKGLGISYGRK`		observed variant
`HCQVCFISKGLGIpYGRK`		observed variant
`HCQVCFISKGLGIn-GRK`		observed variant
`HCQVCFISKGLGIS-GRK`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`5112`
Epitope Seq.	`HCQVCFISKGLGISYGRK`
Variant Seq.	`CFHCQVCFItKGLGISYGRK`
Mutations	S/T
Epitope Location	S8T
HXB2 Location	S40T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons variant (CF)HCQVCFItKGLGISYGRK, with a 2 AA N-terminus extension relative to B cons indicated by parentheses, elicited a CTL response in patient MM48 with mutational escape within the nested epitope ITKGLGISY suggested by Fig. 5 of Turnbull2009.

Variant ID.	`5126`
Epitope Seq.	`HCQVCFISKGLGISYGRK`
Variant Seq.	`HCQVCFISKGLGIpYGRK`
Mutations	S/P
Epitope Location	S14P
HXB2 Location	S46P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant HCQVCFISKGLGIpYGRK was observed in MM39 at 6 mo following onset of symptoms.

Variant ID.	`5127`
Epitope Seq.	`HCQVCFISKGLGISYGRK`
Variant Seq.	`HCQVCFISKGLGIn-GRK`
Mutations	S/N Y/-
Epitope Location	S14N Y15-
HXB2 Location	S46N Y47-
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant HCQVCFISKGLGIn-GRK was observed in MM39 at 6 mo following onset of symptoms.

Variant ID.	`5128`
Epitope Seq.	`HCQVCFISKGLGISYGRK`
Variant Seq.	`HCQVCFISKGLGIS-GRK`
Mutations	Y/-
Epitope Location	Y15-
HXB2 Location	Y47-
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant HCQVCFISKGLGIS-GRK was observed in MM39 at 6 mo following onset of symptoms.

References

Displaying record number 53236

HXB2 Location Tat(36-45) Tat Epitope Map
View variants at this location

Epitope

VCFMTKGLGI

Epitope Alignment

Variants

`VCFtTKGLGI`		escape documented in this paper
`VCFtTeGLGI`		observed variant
`VCFMkKGLGI`		escape documented in this paper

Epitope Name Tat VI10

Species (MHC/HLA) human(B*15:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`540`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFtTKGLGI`
Mutations	M/T
Epitope Location	M4T
HXB2 Location	M39T
Mutation Type	E: escape documented in this paper
Note	The variant was evident during acute phase of infection. The substitution abrogated responses to the epitope.

Variant ID.	`541`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFtTeGLGI`
Mutations	M/T K/E
Epitope Location	M4T K6E
HXB2 Location	M39T K41E
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`542`
Epitope Seq.	`VCFMTKGLGI`
Variant Seq.	`VCFMkKGLGI`
Mutations	T/K
Epitope Location	T5K
HXB2 Location	T40K
Mutation Type	E: escape documented in this paper
Note	The mutation was evident at day 69 and the variant was not recognized.

References

Displaying record number 53237

HXB2 Location Tat(39-47) Tat Epitope Map
View variants at this location

Epitope

MTKGLGISY

Epitope Alignment

Variants

`tTKGLGISY`		susceptible form
`tTeGLGISY`		observed variant
`MkKGLGISY`		inferred escape; processing

Epitope Name Tat MY9

Species (MHC/HLA) human(B*15:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`543`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`tTKGLGISY`
Mutations	M/T
Epitope Location	M1T
HXB2 Location	M39T
Mutation Type	SF: susceptible form
Note	The variant was evident during acute phase of infection. The substitution did not abrogate responses to the epitope.

Variant ID.	`544`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`tTeGLGISY`
Mutations	M/T K/E
Epitope Location	M1T K3E
HXB2 Location	M39T K41E
Mutation Type	OV: observed variant
Note	1/20 clones, variant found at time point 20.

Variant ID.	`545`
Epitope Seq.	`MTKGLGISY`
Variant Seq.	`MkKGLGISY`
Mutations	T/K
Epitope Location	T2K
HXB2 Location	T40K
Mutation Type	IE: inferred escape P: processing
Note	This mutation was evident at day 69. CTL response was strong to the variant, but the substitution seemed to impact processing of the epitope.

References

Displaying record number 63079

HXB2 Location Rev(65-82) Rev Epitope Map
View variants at this location

Epitope

GRPAEPVPLQLPPLERLT

Epitope Alignment

Variants

GRPtEPVPLQLPPLERLT observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5148`
Epitope Seq.	`GRPAEPVPLQLPPLERLT`
Variant Seq.	`GRPtEPVPLQLPPLERLT`
Mutations	A/T
Epitope Location	A4T
HXB2 Location	A68T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	At 6 mo FOSx, autologous variant GRPtEPVPLQLPPLERLT was observed, along with index peptide, in patient MM45.

References

Displaying record number 57556

HXB2 Location Rev(66-75) Rev Epitope Map
View variants at this location

Epitope

RPAELVLQL

Epitope Alignment

Variants

`RstELVLQL`		escape documented in this paper
`RPtAELVLQL`		escape documented in this paper

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2528`
Epitope Seq.	`RPAELVLQL`
Variant Seq.	`RstELVLQL`
Mutations	P/S A/T
Epitope Location	P2S A3T
HXB2 Location	P67S A68T
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD4 T-cell Elispot - IFNy
Note	The variants RstELVLQL and RPtAELVLQL evolved to dominate the quasispecies, and were less well recognized than the index peptide by the PBMC from time points around the time of response decline, indicating escape.

Variant ID.	`2529`
Epitope Seq.	`RPAELVLQL`
Variant Seq.	`RPtAELVLQL`
Mutations	-/T
Epitope Location	-2T
HXB2 Location	-67T
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD4 T-cell Elispot - IFNy
Note	The variants RstELVLQL and RPtAELVLQL evolved to dominate the quasispecies, and were less well recognized than the index peptide by the PBMC from time points around the time of response decline, indicating escape.

References

Displaying record number 62955

HXB2 Location gp160(1-19) gp160 Epitope Map
View variants at this location

Epitope

MKVKGIRKNWHNLGKWGS

Epitope Alignment

Variants

MKVrGIRKNWHNLGKWGS observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5131`
Epitope Seq.	`MKVKGIRKNWHNLGKWGS`
Variant Seq.	`MKVrGIRKNWHNLGKWGS`
Mutations	K/R
Epitope Location	K4R
HXB2 Location	K4R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant MKVrGIRKNWHNLGKWGS was observed at 6 mo following onset of symptoms in patient MM43.

References

Displaying record number 62981

HXB2 Location gp160(6-20) gp160 Epitope Map
View variants at this location

Epitope

NYQHLWRGGIMLLWRGIM

Epitope Alignment

Variants

NYQHLWRGGIsLLWRGIM observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5138`
Epitope Seq.	`NYQHLWRGGIMLLWRGIM`
Variant Seq.	`NYQHLWRGGIsLLWRGIM`
Mutations	M/S
Epitope Location	M11S
HXB2 Location	M16S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	Autologous variant NYQHLWRGGIsLLWRGIM was observed at 6 months following onset of symptoms in patient MM43.

References

Displaying record number 53226

HXB2 Location gp160(31-39) gp160 Epitope Map
View variants at this location

Epitope

AENLWVTVY

Epitope Alignment

Variants

`AaNLWVTaY`		diminished response
`AEkLWVTVY`		diminished response
`AENLgVTVY`		diminished response
`tENLWVTVY`		susceptible form
`vENsWVTVY`		diminished response
`tEkLWVTVY`		diminished response
`AgNLWVTVY`		diminished response
`AaNLWVTVY`		escape documented in this paper
`AkNLWVTVY`		escape documented in this paper
`tENLWVTiY`		susceptible form

Epitope Name gp160 AY9

Species (MHC/HLA) human(B*44:03)

Variant Details

Showing all: 10 variant(s).

Variant ID.	`546`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AaNLWVTaY`
Mutations	E/A V/A
Epitope Location	E2A V8A
HXB2 Location	E32A V38A
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`547`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AEkLWVTVY`
Mutations	N/K
Epitope Location	N3K
HXB2 Location	N33K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`548`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AENLgVTVY`
Mutations	W/G
Epitope Location	W5G
HXB2 Location	W35G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`549`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tENLWVTVY`
Mutations	A/T
Epitope Location	A1T
HXB2 Location	A31T
Mutation Type	SF: susceptible form
Note	Variant did not diminish CTL response.

Variant ID.	`550`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`vENsWVTVY`
Mutations	A/V L/S
Epitope Location	A1V L4S
HXB2 Location	A31V L34S
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`551`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tEkLWVTVY`
Mutations	A/T N/K
Epitope Location	A1T N3K
HXB2 Location	A31T N33K
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`552`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AgNLWVTVY`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E32G
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`553`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AaNLWVTVY`
Mutations	E/A
Epitope Location	E2A
HXB2 Location	E32A
Mutation Type	E: escape documented in this paper
Note	Confirmed escape by dramatic decrease in CTL response.

Variant ID.	`554`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AkNLWVTVY`
Mutations	E/K
Epitope Location	E2K
HXB2 Location	E32K
Mutation Type	E: escape documented in this paper
Note	Confirmed escape by dramatic decrease in CTL response.

Variant ID.	`555`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`tENLWVTiY`
Mutations	A/T V/I
Epitope Location	A1T V8I
HXB2 Location	A31T V38I
Mutation Type	SF: susceptible form
Note	Elicited strong CTL response

References

Displaying record number 53219

HXB2 Location gp160(209-217) gp160 Epitope Map
View variants at this location

Epitope

SFEPIPIHY

Epitope Alignment

Variants

`SFdPIPIHY`		diminished response
`SFEPIPIHf`		diminished response
`SiEPIPIHf`		diminished response
`tFEPIPIHY`		diminished response
`SsEPIPIHY`		observed variant
`SFEPIPInY`		observed variant
`SFEPIPIdf`		observed variant

Epitope Name gp160 SY9

Species (MHC/HLA) human(A*29:02)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`556`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFdPIPIHY`
Mutations	E/D
Epitope Location	E3D
HXB2 Location	E211D
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`557`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPIHf`
Mutations	Y/F
Epitope Location	Y9F
HXB2 Location	Y217F
Mutation Type	DR: diminished response
Note	Variant found in two patients, somewhat reduced CTL response.

Variant ID.	`558`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SiEPIPIHf`
Mutations	F/I Y/F
Epitope Location	F2I Y9F
HXB2 Location	F210I Y217F
Mutation Type	DR: diminished response
Note	Rare form found at day 218. Weakest CTL response.

Variant ID.	`559`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`tFEPIPIHY`
Mutations	S/T
Epitope Location	S1T
HXB2 Location	S209T
Mutation Type	DR: diminished response
Note	Confirmed some degree of escape by reduction of CTL response.

Variant ID.	`560`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SsEPIPIHY`
Mutations	F/S
Epitope Location	F2S
HXB2 Location	F210S
Mutation Type	OV: observed variant
Note	1/10 clones present at time point 41.

Variant ID.	`561`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPInY`
Mutations	H/N
Epitope Location	H8N
HXB2 Location	H216N
Mutation Type	OV: observed variant
Note	7/34 clones present at time point 212 and 4/14 clones at time point 295.

Variant ID.	`562`
Epitope Seq.	`SFEPIPIHY`
Variant Seq.	`SFEPIPIdf`
Mutations	H/D Y/F
Epitope Location	H8D Y9F
HXB2 Location	H216D Y217F
Mutation Type	OV: observed variant
Note	1/11 clones present at time point 136.

References

Displaying record number 63072

HXB2 Location gp160(213-230) gp160 Epitope Map
View variants at this location

Epitope

IPIHYCAPAGFAILKCNN

Epitope Alignment

Variants

IPIHYCAPAGFAILKCNdKK observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5102`
Epitope Seq.	`IPIHYCAPAGFAILKCNN`
Variant Seq.	`IPIHYCAPAGFAILKCNdKK`
Mutations	N/D
Epitope Location	N18D
HXB2 Location	N230D
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons peptide IPIHYCAPAGFAILKCNd(KK), with a 2 AA C-terminus extension, elicited a CTL response in 1/14 patients (MM48) assessed for B cons peptides.

References

Displaying record number 62952

HXB2 Location gp160(213-232) gp160 Epitope Map
View variants at this location

Epitope

IPIHYCAPAGFAILKCNDKK

Epitope Alignment

Variants

IPIHYCAPAGFAILKCNn observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5088`
Epitope Seq.	`IPIHYCAPAGFAILKCNDKK`
Variant Seq.	`IPIHYCAPAGFAILKCNn`
Mutations	D/N
Epitope Location	D18N
HXB2 Location	D230N
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Other
Note	Autologous variant IPIHYCAPAGFAILKCNn, truncated by 2 AA vs. B cons peptide IPIHYCAPAGFAILKCNDKK, is 1/15 immunogenic peptides targeted by HIV-specific sub-dominant T-cell responses in patient MM43.

References

Displaying record number 53220

HXB2 Location gp160(239-247) gp160 Epitope Map
View variants at this location

Epitope

CKNVSTVQC

Epitope Alignment

Variants

`CeNVSTVQC`		inferred escape
`CeNVSTVhC`		inferred escape
`CgNVSTVQC`		observed variant

Epitope Name gp160 CC9

Species (MHC/HLA) human(C*08:02)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`563`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CeNVSTVQC`
Mutations	K/E
Epitope Location	K2E
HXB2 Location	K240E
Mutation Type	IE: inferred escape
Note	4 variants found in the patient. This one and cCeNVSTVhC came up first, at day 6. This variant persisted. Not tested for impact on escape.

Variant ID.	`564`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CeNVSTVhC`
Mutations	K/E Q/H
Epitope Location	K2E Q8H
HXB2 Location	K240E Q246H
Mutation Type	IE: inferred escape
Note	4 variants found in the patient. This one and CeNVSTVQC came up first, at day 6. Not tested for impact on escape.

Variant ID.	`565`
Epitope Seq.	`CKNVSTVQC`
Variant Seq.	`CgNVSTVQC`
Mutations	K/G
Epitope Location	K2G
HXB2 Location	K240G
Mutation Type	OV: observed variant
Note	Rare variant present at day 35. Not tested for impact on escape.

References

Displaying record number 53221

HXB2 Location gp160(584-592) gp160 Epitope Map
View variants at this location

Epitope

ERYLKDQQL

Epitope Alignment

Variants

`ERYLKeQQp`		observed variant
`ERYLrDQQL`		susceptible form
`ERYLtDQQL`		diminished response
`ERYLqDQQL`		diminished response
`ERYLsDQQL`		diminished response
`ERYLmDQQL`		diminished response
`ERYLmDQrL`		observed variant
`ERYLmDrQL`		observed variant
`ERYLmDQlL`		observed variant
`ERYLtDQrL`		observed variant
`ERYrtDQrL`		observed variant

Epitope Name gp160 EL9

Species (MHC/HLA) human

Variant Details

Showing all: 11 variant(s).

Variant ID.	`578`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLKeQQp`
Mutations	D/E L/P
Epitope Location	D6E L9P
HXB2 Location	D589E L592P
Mutation Type	OV: observed variant
Note	Came up at day 17. Not tested for escape.

Variant ID.	`579`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLrDQQL`
Mutations	K/R
Epitope Location	K5R
HXB2 Location	K588R
Mutation Type	SF: susceptible form
Note	Came up at day 31, did not confer escape.

Variant ID.	`580`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLtDQQL`
Mutations	K/T
Epitope Location	K5T
HXB2 Location	K588T
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response.

Variant ID.	`581`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLqDQQL`
Mutations	K/Q
Epitope Location	K5Q
HXB2 Location	K588Q
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response. Also found in another patient.

Variant ID.	`582`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLsDQQL`
Mutations	K/S
Epitope Location	K5S
HXB2 Location	K588S
Mutation Type	DR: diminished response
Note	One of the three variants found at day 218, gave diminished CTL response.

Variant ID.	`583`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQQL`
Mutations	K/M
Epitope Location	K5M
HXB2 Location	K588M
Mutation Type	DR: diminished response
Note	Found at day 556, gave a further reduction of CTL response.

Variant ID.	`584`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQrL`
Mutations	K/M Q/R
Epitope Location	K5M Q8R
HXB2 Location	K588M Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`585`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDrQL`
Mutations	K/M Q/R
Epitope Location	K5M Q7R
HXB2 Location	K588M Q590R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`586`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLmDQlL`
Mutations	K/M Q/L
Epitope Location	K5M Q8L
HXB2 Location	K588M Q591L
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`587`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYLtDQrL`
Mutations	K/T Q/R
Epitope Location	K5T Q8R
HXB2 Location	K588T Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

Variant ID.	`588`
Epitope Seq.	`ERYLKDQQL`
Variant Seq.	`ERYrtDQrL`
Mutations	L/R K/T Q/R
Epitope Location	L4R K5T Q8R
HXB2 Location	L587R K588T Q591R
Mutation Type	OV: observed variant
Note	Double mutant found at day 556. Not tested for escape.

References

Displaying record number 62970

HXB2 Location gp160(701-718) gp160 Epitope Map
View variants at this location

Epitope

VLSIVNRVRQGYSPLSLQ

Epitope Alignment

Variants

`VLSIVkRVRkGYSPLSLQ`		observed variant
`VLSIVkRVRQGYSPLSLQ`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5135`
Epitope Seq.	`VLSIVNRVRQGYSPLSLQ`
Variant Seq.	`VLSIVkRVRkGYSPLSLQ`
Mutations	Q/K N/K
Epitope Location	Q10K N6K
HXB2 Location	Q710K N706K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	Autologous variant VLSIVkRVRkGYSPLSLQ was observed at 6 months following onset of symptoms in patient MM42.

Variant ID.	`5136`
Epitope Seq.	`VLSIVNRVRQGYSPLSLQ`
Variant Seq.	`VLSIVkRVRQGYSPLSLQ`
Mutations	N/K
Epitope Location	N6K
HXB2 Location	N706K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	Autologous variant VLSIVkRVRQGYSPLSLQ was observed at 6 months following onset of symptoms in patient MM42.

References

Displaying record number 62947

HXB2 Location gp160(837-856) gp160 Epitope Map
View variants at this location

Epitope

CRAILHIPRRIRQGLERALL

Epitope Alignment

Variants

`RAILHIPRRIRQGLERsL`		observed variant
`RAILHIPtRIRQGLERcL`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5086`
Epitope Seq.	`CRAILHIPRRIRQGLERALL`
Variant Seq.	`RAILHIPRRIRQGLERsL`
Mutations	A/S
Epitope Location	A17S
HXB2 Location	A853S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Other
Note	Autologous variant RAILHIPRRIRQGLERsL was 1/10 peptides targeted by HIV-specific T-cell response in acutely infected patient MM45. Corresponding B cons peptide, CRAILHIPRRIRQGLERALL, is extended 1 AA on both ends.

Variant ID.	`5087`
Epitope Seq.	`CRAILHIPRRIRQGLERALL`
Variant Seq.	`RAILHIPtRIRQGLERcL`
Mutations	A/C R/T
Epitope Location	A17C R8T
HXB2 Location	A853C R844T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Other
Note	Autologous variant RAILHIPtRIRQGLERcL is 1/3 immunogenic peptides targeted by the HIV-specific T-cell response in the first PBMC sample after symptoms onset & 1/10 targets throughout entire study for patient MM33. During the 6 months following symptom onset, sequence variation was not observed and RAILHIPtRIRQGLERcL-specific T cell response was initially subdominant but became dominant by 1-2 months. Corresponding B cons peptide, CRAILHIPRRIRQGLERALL, is extended 1 AA on both ends.

References

Displaying record number 63070

HXB2 Location gp160(838-855) gp160 Epitope Map
View variants at this location

Epitope

RAILHIPRRIRQGLERSL

Epitope Alignment

Variants

`RAILHIPtRIRQGLERcL`		observed variant
`CRAILHIPRRIRQGLERALL`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5098`
Epitope Seq.	`RAILHIPRRIRQGLERSL`
Variant Seq.	`RAILHIPtRIRQGLERcL`
Mutations	S/C R/T
Epitope Location	S17C R8T
HXB2 Location	S854C R845T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant RAILHIPtRIRQGLERcL is 1/3 immunogenic peptides targeted by the HIV-specific T-cell response in the first PBMC sample after symptoms onset & 1/10 targets throughout entire study for patient MM33. During the 6 months following symptom onset, sequence variation was not observed and RAILHIPtRIRQGLERcL-specific T cell response was initially subdominant but became dominant by 1-2 months.

Variant ID.	`5099`
Epitope Seq.	`RAILHIPRRIRQGLERSL`
Variant Seq.	`CRAILHIPRRIRQGLERALL`
Mutations	S/A
Epitope Location	S17A
HXB2 Location	S854A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons peptide CRAILHIPRRIRQGLERALL is extended 1 AA on both ends & elicited CTL responses in 3/14 patients (MM28, MM46, MM50) assessed for B consensus peptides.

References

Displaying record number 63071

HXB2 Location gp160(838-855) gp160 Epitope Map
View variants at this location

Epitope

RAILHIPTRIRQGLERCL

Epitope Alignment

Variants

`CRAILHIPrRIRQGLERaLL`		observed variant
`RAILHIPrRIRQGLERsL`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5100`
Epitope Seq.	`RAILHIPTRIRQGLERCL`
Variant Seq.	`CRAILHIPrRIRQGLERaLL`
Mutations	C/A T/R
Epitope Location	C17A T8R
HXB2 Location	C854A T845R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons peptide CRAILHIPRRIRQGLERALL is extended 1 AA on both ends & elicited CTL responses in 3/14 patients (MM28, MM46, MM50) assessed for B consensus peptides.

Variant ID.	`5101`
Epitope Seq.	`RAILHIPTRIRQGLERCL`
Variant Seq.	`RAILHIPrRIRQGLERsL`
Mutations	C/S T/R
Epitope Location	C17S T8R
HXB2 Location	C854S T845R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant RAILHIPrRIRQGLERsL was 1/10 peptides targeted by HIV-specific T-cell response in acutely infected patient MM45.

References

Displaying record number 63055

HXB2 Location Nef(41-58) Nef Epitope Map
View variants at this location

Epitope

GALTSSNTPSNNATCAWL

Epitope Alignment

Variants

`GAiTSSNTaaNNAdCAWLEA`		observed variant
`GALTSSNTPStNATCAWL`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5097`
Epitope Seq.	`GALTSSNTPSNNATCAWL`
Variant Seq.	`GAiTSSNTaaNNAdCAWLEA`
Mutations	S/A T/D L/I P/A
Epitope Location	S10A T14D L3I P9A
HXB2 Location	S50A T54D L43I P49A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons variant GAiTSSNTaaNNAdCAWL(EA) elicited a CTL response in 1/14 patients, MM55, assessed for B cons peptides responses and has a 2 AA extended C-terminus (indicated by parentheses) compared to immunogenic autologous peptide GALTSSNTPSNNATCAWL observed in patient MM43.

Variant ID.	`5134`
Epitope Seq.	`GALTSSNTPSNNATCAWL`
Variant Seq.	`GALTSSNTPStNATCAWL`
Mutations	N/T
Epitope Location	N11T
HXB2 Location	N51T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	In patient MM43, autologous variant GALTSSNTPStNATCAWL was observed at 6 months following onset of symptoms.

References

Displaying record number 63058

HXB2 Location Nef(41-60) Nef Epitope Map
View variants at this location

Epitope

GAITSSNTAANNADCAWLEA

Epitope Alignment

Variants

GAlTSSNTpsNNAtCAWL observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5096`
Epitope Seq.	`GAITSSNTAANNADCAWLEA`
Variant Seq.	`GAlTSSNTpsNNAtCAWL`
Mutations	A/S D/T I/L A/P
Epitope Location	A10S D14T I3L A9P
HXB2 Location	A50S D54T I43L A49P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant GAlTSSNTpsNNAtCAWL elicited a CTL response in patient MM43 and has a 2 AA truncation (indicated by parentheses) compared to B cons peptide GAITSSNTAANNADCAWL(EA) which was targeted in 1/14 patients, MM55, assessed for B cons peptide responses.

References

Displaying record number 63051

HXB2 Location Nef(65-82) Nef Epitope Map
View variants at this location

Epitope

EVGFPVRPQVPLRPMTYK

Epitope Alignment

Variants

EVGFPVtPQVPLRPMTYK observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5125`
Epitope Seq.	`EVGFPVRPQVPLRPMTYK`
Variant Seq.	`EVGFPVtPQVPLRPMTYK`
Mutations	R/T
Epitope Location	R7T
HXB2 Location	R71T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant EVGFPVtPQVPLRPMTYK was observed at 6 mo following onset of symptoms in patient MM33.

References

Displaying record number 63056

HXB2 Location Nef(81-98) Nef Epitope Map
View variants at this location

Epitope

YKGAVDLSHFLKEKGGLE

Epitope Alignment

Variants

`YKaAVDLSHFLKEKGGLEGL`		observed variant
`YKaAVDLSHFLKEKGGLE`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`5103`
Epitope Seq.	`YKGAVDLSHFLKEKGGLE`
Variant Seq.	`YKaAVDLSHFLKEKGGLEGL`
Mutations	G/A
Epitope Location	G3A
HXB2 Location	G83A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	B cons variant YKaAVDLSHFLKEKGGLE(GL), with a 2 AA extended C-terminus as indicated by parentheses, was a CTL target in 2 other patients: MM23 & MM46.

Variant ID.	`5119`
Epitope Seq.	`YKGAVDLSHFLKEKGGLE`
Variant Seq.	`YKaAVDLSHFLKEKGGLE`
Mutations	G/A
Epitope Location	G3A
HXB2 Location	G83A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant YKaAVDLSHFLKEKGGLE was observed in patient MM33 at 6 months following onset of symptoms.

References

Displaying record number 63069

HXB2 Location Nef(81-100) Nef Epitope Map
View variants at this location

Epitope

YKAAVDLSHFLKEKGGLEGL

Epitope Alignment

Variants

YKgAVDLSHFLKEKGGLE observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5121`
Epitope Seq.	`YKAAVDLSHFLKEKGGLEGL`
Variant Seq.	`YKgAVDLSHFLKEKGGLE`
Mutations	A/G
Epitope Location	A3G
HXB2 Location	A83G
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant YKgAVDLSHFLKEKGGLE, with a 2 AA C-terminus truncation, was observed as a CTL target in patient MM33.

References

Displaying record number 63054

HXB2 Location Nef(121-138) Nef Epitope Map
View variants at this location

Epitope

FPDWQNYTPGPGIRYPLT

Epitope Alignment

Variants

FPDWQNYTPGPGtRYPLT observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5129`
Epitope Seq.	`FPDWQNYTPGPGIRYPLT`
Variant Seq.	`FPDWQNYTPGPGtRYPLT`
Mutations	I/T
Epitope Location	I13T
HXB2 Location	I133T
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant FPDWQNYTPGPGtRYPLT was observed at 6 mo following onset o symptoms in patient MM39.

References

Displaying record number 57557

HXB2 Location Nef(134-143) Nef Epitope Map
View variants at this location

Epitope

RYPLTFGWCF

Epitope Alignment

Variants

RYPLTFGWCy observed variant

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5108`
Epitope Seq.	`RYPLTFGWCF`
Variant Seq.	`RYPLTFGWCy`
Mutations	F/Y
Epitope Location	F10Y
HXB2 Location	F143Y
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	C
Method	Tetramer binding
Note	Variant RYPLTFGWCy elicited a response in subtype C-acutely infected patient MM47.

References

Displaying record number 63067

HXB2 Location Nef(134-143) Nef Epitope Map
View variants at this location

Epitope

RYPLTFGWCY

Epitope Alignment

Variants

RYPLTFGWCf observed variant

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5107`
Epitope Seq.	`RYPLTFGWCY`
Variant Seq.	`RYPLTFGWCf`
Mutations	Y/F
Epitope Location	Y10F
HXB2 Location	Y143F
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	B
Method	Tetramer binding
Note	Variant RYPLTFGWCf elicited a response in subtype B-acutely infected patient MM40.

References

Displaying record number 63050

HXB2 Location Nef(177-194) Nef Epitope Map
View variants at this location

Epitope

EKEVLEWRFDITLAHHHR

Epitope Alignment

Variants

`EgEVLqWkFDsrLAfHHm`		observed variant
`EKEVLqWRFDITLAHHHR`		observed variant
`EKEVLpWRFDITLAHHHR`		observed variant
`EKEVLaWRFDITLAHHHR`		observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`5106`
Epitope Seq.	`EKEVLEWRFDITLAHHHR`
Variant Seq.	`EgEVLqWkFDsrLAfHHm`
Mutations	I/S T/R H/F R/M K/G E/Q R/K
Epitope Location	I11S T12R H15F R18M K2G E6Q R8K
HXB2 Location	I187S T188R H191F R194M K178G E182Q R184K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant EgEVLqWkFDsrLAfHHm was a CTL target in patient MM33.

Variant ID.	`5144`
Epitope Seq.	`EKEVLEWRFDITLAHHHR`
Variant Seq.	`EKEVLqWRFDITLAHHHR`
Mutations	E/Q
Epitope Location	E6Q
HXB2 Location	E182Q
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	At 6 mo following onset of symptoms, 3 autologous variants (EKEVLqWRFDITLAHHHR, EKEVLpWRFDITLAHHHR, EKEVLaWRFDITLAHHHR) & index peptide were observed in MM45.

Variant ID.	`5145`
Epitope Seq.	`EKEVLEWRFDITLAHHHR`
Variant Seq.	`EKEVLpWRFDITLAHHHR`
Mutations	E/P
Epitope Location	E6P
HXB2 Location	E182P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	At 6 mo following onset of symptoms, 3 autologous variants (EKEVLqWRFDITLAHHHR, EKEVLpWRFDITLAHHHR, EKEVLaWRFDITLAHHHR) & index peptide were observed in MM45.

Variant ID.	`5146`
Epitope Seq.	`EKEVLEWRFDITLAHHHR`
Variant Seq.	`EKEVLaWRFDITLAHHHR`
Mutations	E/A
Epitope Location	E6A
HXB2 Location	E182A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study
Note	At 6 mo following onset of symptoms, 3 autologous variants (EKEVLqWRFDITLAHHHR, EKEVLpWRFDITLAHHHR, EKEVLaWRFDITLAHHHR) & index peptide were observed in MM45.

References

Displaying record number 63049

HXB2 Location Nef(177-194) Nef Epitope Map
View variants at this location

Epitope

EGEVLQWKFDSRLAFHHM

Epitope Alignment

Variants

EkEVLeWrFDitLAhHHr observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5105`
Epitope Seq.	`EGEVLQWKFDSRLAFHHM`
Variant Seq.	`EkEVLeWrFDitLAhHHr`
Mutations	S/I R/T F/H M/R G/K Q/E K/R
Epitope Location	S11I R12T F15H M18R G2K Q6E K8R
HXB2 Location	S187I R188T F191H M194R G178K Q182E K184R
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy
Note	Autologous variant EkEVLeWrFDitLAhHHr was identified as a CTL target in patient MM43.

References

Displaying record number 63052

HXB2 Location Nef(185-202) Nef Epitope Map
View variants at this location

Epitope

FDSRLAFHHIARELHPEY

Epitope Alignment

Variants

FDSlLAFHHIARELHPEY observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`5130`
Epitope Seq.	`FDSRLAFHHIARELHPEY`
Variant Seq.	`FDSlLAFHHIARELHPEY`
Mutations	R/L
Epitope Location	R4L
HXB2 Location	R188L
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Autologous variant FDSlLAFHHIARELHPEY was observed at 6 mo following onset of symptoms in patient MM42.