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Found 3 matching records:

Displaying record number 52791

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLfNTVATL`		escape documented in this paper; susceptible form; TCR related mutation
`SLYNTiATL`		escape documented in this paper
`SLYNTiAvL`		escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
`SLfNTiATL`		escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
`SLYNlVAvL`		escape documented in this paper; non-susceptible form; TCR related mutation
`SLYNTVAaL`		observed variant

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1856`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	E: escape documented in this paper SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 161JxA14 recognizes this variant but Clone 18030D23 from a different subject does not. Both clones recognize SL9 index sequence similarly.

Variant ID.	`1857`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of selective pressure by culturing with 1 of 4 SL9-specific clones i.e. 161JxA14, this variant arose and was not recognized.

Variant ID.	`1858`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiAvL`
Mutations	V/I T/V
Epitope Location	V6I T8V
HXB2 Location	V82I T84V
Mutation Type	E: escape documented in this paper NSF: non-susceptible form SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 Clade B index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1859`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiATL`
Mutations	Y/F V/I
Epitope Location	Y3F V6I
HXB2 Location	Y79F V82I
Mutation Type	E: escape documented in this paper NSF: non-susceptible form SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1860`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNlVAvL`
Mutations	T/L T/V
Epitope Location	T5L T8V
HXB2 Location	T81L T84V
Mutation Type	E: escape documented in this paper NSF: non-susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clones 18030D23 and 161JxA14 from different subjects do not recognize this variant. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1861`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T84A
Mutation Type	OV: observed variant
Method	Chromium-release assay, Sequence
Note	This minority epitope variant was seen after 2 weeks of selection by SL9-specific clone 18030D23.

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.

Displaying record number 52787

HXB2 Location Pol(464-472) Pol Epitope Map
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Epitope

ILKEPVHGV

Epitope Alignment

Variants

ILKElVHGV escape documented in this paper

Epitope Name IV9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1862`
Epitope Seq.	`ILKEPVHGV`
Variant Seq.	`ILKElVHGV`
Mutations	P/L
Epitope Location	P5L
HXB2 Location	P468L
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by IV9-specific clone 68A62, this escape variant that was not recognized emerged.

References

Displaying record number 52790

HXB2 Location Nef(92-100) Nef Epitope Map
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Epitope

KEKGGLEGL

Epitope Alignment

Variants

`KEKGGLEGi`		escape documented in this paper
`KkKGGLEGL`		escape documented in this paper
`KEKGGLEGp`		escape documented in this paper
`KEKGGLEeL`		escape documented in this paper
`KEKGGLErL`		escape documented in this paper
`KEKrGLErL`		escape documented in this paper
`KEnGGLEGL`		escape documented in this paper

Epitope Name KL9

Species (MHC/HLA) human(B60)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`1863`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKGGLEGi`
Mutations	L/I
Epitope Location	L9I
HXB2 Location	L100I
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After one round of week-long passaging under selection by KL9-specific CTL clone, STD11, this mutation was seen. It was not recognized.

Variant ID.	`1864`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KkKGGLEGL`
Mutations	E/K
Epitope Location	E2K
HXB2 Location	E93K
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After one round of week-long passaging under selection by KL9-specific CTL clone, STD11, this mutation was seen. It was not recognized.

Variant ID.	`1865`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKGGLEGp`
Mutations	L/P
Epitope Location	L9P
HXB2 Location	L100P
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.

Variant ID.	`1866`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKGGLEeL`
Mutations	G/E
Epitope Location	G8E
HXB2 Location	G99E
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.

Variant ID.	`1867`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKGGLErL`
Mutations	G/R
Epitope Location	G8R
HXB2 Location	G99R
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.

Variant ID.	`1868`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEKrGLErL`
Mutations	G/R G/R
Epitope Location	G4R G8R
HXB2 Location	G95R G99R
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.

Variant ID.	`1869`
Epitope Seq.	`KEKGGLEGL`
Variant Seq.	`KEnGGLEGL`
Mutations	K/N
Epitope Location	K3N
HXB2 Location	K94N
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.