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Found 6 matching records:

Displaying record number 57700

HXB2 Location  Gag(21-35)   Gag Epitope Map
View variants at this location
Epitope LRPGGKKKYKLKHIV   Epitope Alignment
Variants
LRPGGKKqYKLKHIV   susceptible form
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2594
Epitope Seq.  LRPGGKKKYKLKHIV
Variant Seq.  LRPGGKKqYKLKHIV
Mutations K/Q
Epitope Location K8Q
HXB2 Location K28Q
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note CTL response to variant LRPGGKKqYKLKHIV was also detected 48 weeks after TI began.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 57701

HXB2 Location  Gag(28-36)   Gag Epitope Map
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Epitope KYKLKHIVW   Epitope Alignment
Variants
qYKLKHIVW   susceptible form
Species (MHC/HLA human(A*23)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2595
Epitope Seq.  KYKLKHIVW
Variant Seq.  qYKLKHIVW
Mutations K/Q
Epitope Location K1Q
HXB2 Location K28Q
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant qYKLKHIVW also elicited CTL response 48 weeks after start of TI in Patient 311.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 57703

HXB2 Location  Gag(71-79)   Gag Epitope Map
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Epitope GSEELKSLY   Epitope Alignment
Variants
GSEELrSLY   susceptible form
Species (MHC/HLA human(A*01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2597
Epitope Seq.  GSEELKSLY
Variant Seq.  GSEELrSLY
Mutations K/R
Epitope Location K6R
HXB2 Location K76R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant GSEELrSLY also elicited CTL responses all through TI in Patient 311.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 57702

HXB2 Location  Gag(74-82)   Gag Epitope Map
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Epitope ELKSLYNTV   Epitope Alignment
Variants
ELrSLYNTV   susceptible form
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2601
Epitope Seq.  ELKSLYNTV
Variant Seq.  ELrSLYNTV
Mutations K/R
Epitope Location K3R
HXB2 Location K76R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant ELrSLYNTV also was recognized through TI in Patient 311.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 57708

HXB2 Location  Gag(82-92)   Gag Epitope Map
View variants at this location
Epitope VATLYCVHQRI   Epitope Alignment
Variants
VvTLYCVHQRI   susceptible form
Species (MHC/HLA human(A*11)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2600
Epitope Seq.  VATLYCVHQRI
Variant Seq.  VvTLYCVHQRI
Mutations A/V
Epitope Location A2V
HXB2 Location A83V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant at anchor position 2, VvTLYCVHQRI, also elicited CTL response but from week 24 after TI began in Patient 313.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 57704

HXB2 Location  Gag(93-101)   Gag Epitope Map
View variants at this location
Epitope EIKDTKEAL   Epitope Alignment
Variants
EvKDTKEAL   susceptible form
dvKDTKEAL   susceptible form
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2598
Epitope Seq.  EIKDTKEAL
Variant Seq.  EvKDTKEAL
Mutations I/V
Epitope Location I2V
HXB2 Location I94V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant EvKDTKEAL was recognized by CTL 48 weeks into TI, in Patient 311.


Variant ID.  2599
Epitope Seq.  EIKDTKEAL
Variant Seq.  dvKDTKEAL
Mutations E/D I/V
Epitope Location E1D I2V
HXB2 Location E93D I94V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Gag variant dvKDTKEAL was recognized by CTL 48 weeks into TI, in Patient 311.

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


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