HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 57650

HXB2 Location  Gag(151-159)   Gag Epitope Map
View variants at this location
Epitope TLNAWVKVV   Epitope Alignment
kINAWiKVV   susceptible form
Epitope Name TV9
Species (MHC/HLA (A*02:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  2569
Epitope Seq.  TLNAWVKVV
Variant Seq.  kINAWiKVV
Mutations T/K L/I V/I
Epitope Location T1K L2I V6I
HXB2 Location T151K L152I V156I
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding
Note This is a mimic peptide shown to consistently activate cross-reactive and equally functional CTLs as measured by cytotoxicity, cytokine production and suppression of HIV replication in vitro.


Schaubert2010 Keri L. Schaubert, David A. Price, Janelle R. Salkowitz, Andrew K. Sewell, John Sidney, Tedi E. Asher, Sylvie E. Blondelle, Sharon Adams, Francesco M. Marincola, Aviva Joseph, Alessandro Sette, Daniel C. Douek, Velpandi Ayyavoo, Walter Storkus, Ming-Ying Leung, Hwee L. Ng, Otto O. Yang, Harris Goldstein, Darcy B. Wilson, and June Kan-Mitchell. Generation of Robust CD8+ T-Cell Responses Against Subdominant Epitopes in Conserved Regions of HIV-1 by Repertoire Mining with Mimotopes. Eur. J. Immunol., 40(7):1950-1962, Jul 2010. PubMed ID: 20432235. Show all entries for this paper.

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