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Found 15 matching records:

Displaying record number 53844

HXB2 Location Gag(11-19) Gag Epitope Map
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Epitope

GELDRWEKI

Epitope Alignment

Variants

GELDRWkKI diminished response; literature escape

Epitope Name GI9

Species (MHC/HLA) human(B*40)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1569`
Epitope Seq.	`GELDRWEKI`
Variant Seq.	`GELDRWkKI`
Mutations	E/K
Epitope Location	E7K
HXB2 Location	E17K
Mutation Type	DR: diminished response LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-B40-carrying mother, M-1002, but was never detected in her non-HLA-B40-carrying infant, P-1031. Decreased recognition of the E17K variant relative to the index epitope was seen in the mother.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.

Displaying record number 53838

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

KIRLRPGGr literature escape; observed variant

Epitope Name KR9

Species (MHC/HLA) human(A*03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1570`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`KIRLRPGGr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K26R
Mutation Type	LE: literature escape OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Displaying record number 53839

HXB2 Location Gag(20-29) Gag Epitope Map
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Epitope

RLRPGGKKKY

Epitope Alignment

Variants

`RLRPGGKKqY`		diminished response
`RLRPGGKKrY`		diminished response

Epitope Name RY10

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1571`
Epitope Seq.	`RLRPGGKKKY`
Variant Seq.	`RLRPGGKKqY`
Mutations	K/Q
Epitope Location	K9Q
HXB2 Location	K28Q
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1003, as well as her non-HLA-A30-carrying infant, P-1189. Decreased recognition of the variant was seen relative to index epitope. This variant was still detected at 12 months of age in Infant P-1189.

Variant ID.	`1572`
Epitope Seq.	`RLRPGGKKKY`
Variant Seq.	`RLRPGGKKrY`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K28R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1002, as well as her HLA-A30-carrying infant, P-1031. Decreased recognition of the variant was seen relative to index epitope in the mother. The variant was detected at decreasing frequencies by 11 months of age in infant P-1031, but recognition was equivalent to index epitope recognition in the infant.

References

Displaying record number 53840

HXB2 Location Gag(24-31) Gag Epitope Map
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Epitope

GGKKKYKL

Epitope Alignment

Variants

GGrKKYKL reversion

Epitope Name GL8

Species (MHC/HLA) human(B*08)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1573`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGrKKYKL`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K26R
Mutation Type	R: reversion
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-B8 allele carrying mother, M-1001, as well as her non-HLA-B8-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Displaying record number 53841

HXB2 Location Gag(28-36) Gag Epitope Map
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Epitope

KYKLKHIVW

Epitope Alignment

Variants

qYKLKHIVW escape documented in this paper; literature escape

Epitope Name QW9

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1574`
Epitope Seq.	`KYKLKHIVW`
Variant Seq.	`qYKLKHIVW`
Mutations	K/Q
Epitope Location	K1Q
HXB2 Location	K28Q
Mutation Type	E: escape documented in this paper LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her HLA-A24-carrying infant, P-1189. Decreased recognition of the variant was seen relative to wild type index epitope. This variant was still detected at 12 months of age in infant P-1189. While the mother could recognize index epitope QW9, but not this variant, infant P-1189 could not recognize either index or variant.

References

Displaying record number 53842

HXB2 Location Gag(250-258) Gag Epitope Map
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Epitope

MTNNPPIPV

Epitope Alignment

Variants

MThNPPIPV observed variant

Epitope Name MV9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1575`
Epitope Seq.	`MTNNPPIPV`
Variant Seq.	`MThNPPIPV`
Mutations	N/H
Epitope Location	N3H
HXB2 Location	N252H
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the non-HLA-A2 allele carrying mother, M-1004, as well as her restricting-HLA-A2-carrying infant, P-1115. This variant was still detected at 12 months of age in infant P-1115.

References

Displaying record number 53843

HXB2 Location Gag(362-370) Gag Epitope Map
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Epitope

VLAEAMSQV

Epitope Alignment

Variants

VLAEAMShV observed variant

Epitope Name VV9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1576`
Epitope Seq.	`VLAEAMSQV`
Variant Seq.	`VLAEAMShV`
Mutations	Q/H
Epitope Location	Q8H
HXB2 Location	Q369H
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A2 allele carrying mother, M-1005, as well as her non-HLA-A2-carrying infant, P-1026. This variant was still detected at 15 months of age in infant P-1026.

References

Displaying record number 53845

HXB2 Location Gag(481-489) Gag Epitope Map
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Epitope

KELYPLTSL

Epitope Alignment

Variants

KEmYPLaSL observed variant

Epitope Name KL9

Species (MHC/HLA) human(B*40)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1577`
Epitope Seq.	`KELYPLTSL`
Variant Seq.	`KEmYPLaSL`
Mutations	L/M T/A
Epitope Location	L3M T7A
HXB2 Location	L483M T487A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-B40 allele carrying mother, M-1005, as well as her non-HLA-B40-carrying infant, P-1026. This variant was still detected at 15 months of age in infant P-1026.

References

Displaying record number 53846

HXB2 Location Nef(13-20) Nef Epitope Map
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Epitope

WPTVRERM

Epitope Alignment

Variants

WnTVRERM observed variant

Epitope Name WM8

Species (MHC/HLA) human(B*08)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1578`
Epitope Seq.	`WPTVRERM`
Variant Seq.	`WnTVRERM`
Mutations	P/N
Epitope Location	P2N
HXB2 Location	P14N
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-B8 allele carrying mother, M-1001, as well as her non-HLA-B8-carrying infant, P-1024. The variant was still detected at 15 months of age in infant P-1024.

References

Displaying record number 53847

HXB2 Location Nef(77-85) Nef Epitope Map
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Epitope

RPMTYKAAL

Epitope Alignment

Variants

RPMThqAAw diminished response; susceptible form

Epitope Name RW9

Species (MHC/HLA) human(B*07)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1579`
Epitope Seq.	`RPMTYKAAL`
Variant Seq.	`RPMThqAAw`
Mutations	Y/H K/Q L/W
Epitope Location	Y5H K6Q L9W
HXB2 Location	Y81H K82Q L85W
Mutation Type	DR: diminished response SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the non-HLA-B7 allele carrying mother, M-1003, as well as her restricting-HLA-B7-carrying infant, P-1189. The variant was still detected at 12 months of age in infant P-1189. Decreased recognition of the variant was seen relative to index epitope in the mother, but recognition was equivalent to index epitope recognition in the infant.

References

Displaying record number 53848

HXB2 Location Nef(83-91) Nef Epitope Map
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Epitope

AAVDLSHFL

Epitope Alignment

Variants

`AAVDmSHFL`		diminished response; literature escape
`gAlDLSHFL`		observed variant

Epitope Name AL9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1580`
Epitope Seq.	`AAVDLSHFL`
Variant Seq.	`AAVDmSHFL`
Mutations	L/M
Epitope Location	L5M
HXB2 Location	L87M
Mutation Type	DR: diminished response LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the non-HLA-A2 allele carrying mother, M-1002, as well as her restricting-HLA-A2-carrying infant, P-1031. The variant was still detected at 12 months of age in infant P-1031. Decreased recognition of the variant was seen relative to index epitope, in time.

Variant ID.	`1581`
Epitope Seq.	`AAVDLSHFL`
Variant Seq.	`gAlDLSHFL`
Mutations	A/G V/L
Epitope Location	A1G V3L
HXB2 Location	A83G V85L
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A2 allele carrying mother, M-1005, as well as her non-HLA-A2-carrying infant, P-1026. The variant was still detected at 15 months of age in infant P-1026.

References

Displaying record number 53849

HXB2 Location Nef(84-92) Nef Epitope Map
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Epitope

AVDLSHFLK

Epitope Alignment

Variants

AmDLSHFLK observed variant

Epitope Name AK9

Species (MHC/HLA) human(A*03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1582`
Epitope Seq.	`AVDLSHFLK`
Variant Seq.	`AmDLSHFLK`
Mutations	V/M
Epitope Location	V2M
HXB2 Location	V85M
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Displaying record number 53852

HXB2 Location Nef(134-143) Nef Epitope Map
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Epitope

RYPLTFGWCF

Epitope Alignment

Variants

`RfPLTFGWCF`		literature escape; observed variant
`kfPLTFGWCF`		observed variant
`RYPLTlGWCF`		inferred escape

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1583`
Epitope Seq.	`RYPLTFGWCF`
Variant Seq.	`RfPLTFGWCF`
Mutations	Y/F
Epitope Location	Y2F
HXB2 Location	Y135F
Mutation Type	LE: literature escape OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026, becoming the predominant form by 13 months. This Y135F mutation is a previously described escape in hemophiliacs.

Variant ID.	`1584`
Epitope Seq.	`RYPLTFGWCF`
Variant Seq.	`kfPLTFGWCF`
Mutations	R/K Y/F
Epitope Location	R1K Y2F
HXB2 Location	R134K Y135F
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026 at a very low copy number.

Variant ID.	`1585`
Epitope Seq.	`RYPLTFGWCF`
Variant Seq.	`RYPLTlGWCF`
Mutations	F/L
Epitope Location	F6L
HXB2 Location	F139L
Mutation Type	IE: inferred escape
Method	Sequence
Note	This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026.

References

Displaying record number 53850

HXB2 Location Nef(186-194) Nef Epitope Map
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Epitope

DSRLAFHHM

Epitope Alignment

Variants

`DSRLAFqHM`		diminished response; literature escape
`DStLAFqHk`		diminished response; literature escape

Epitope Name DM9

Species (MHC/HLA) human(A*24)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1586`
Epitope Seq.	`DSRLAFHHM`
Variant Seq.	`DSRLAFqHM`
Mutations	H/Q
Epitope Location	H7Q
HXB2 Location	H192Q
Mutation Type	DR: diminished response LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the non-HLA-A24 allele carrying mother, M-1001, as well as her restricting HLA-A24-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age. Decreased recognition of the variant was seen relative to the index epitope.

Variant ID.	`1587`
Epitope Seq.	`DSRLAFHHM`
Variant Seq.	`DStLAFqHk`
Mutations	R/T H/Q M/K
Epitope Location	R3T H7Q M9K
HXB2 Location	R188T H192Q M194K
Mutation Type	DR: diminished response LE: literature escape
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her restricting HLA-A24-carrying infant, P-1089. This variant was still detected at 15 months of age. Decreased recognition of the variant was seen relative to the index epitope.

References

Displaying record number 53851

HXB2 Location Nef(190-198) Nef Epitope Map
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Epitope

AFHHVAREK

Epitope Alignment

Variants

AFqHmAREl observed variant

Epitope Name AL9

Species (MHC/HLA) human(A*03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1588`
Epitope Seq.	`AFHHVAREK`
Variant Seq.	`AFqHmAREl`
Mutations	H/Q V/M K/L
Epitope Location	H3Q V5M K9L
HXB2 Location	H192Q V194M K198L
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.